Effects of ibotenic acid lesions of the ventral striatum and the medial prefrontal cortex on ethanol consumption in the rat

Alcohol ◽  
1995 ◽  
Vol 12 (5) ◽  
pp. 397-402 ◽  
Author(s):  
S. Hansen ◽  
C. Fahlke ◽  
E. Hård ◽  
R. Thomasson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ventral Striatum ◽  
Ibotenic Acid ◽  
Ethanol Consumption

Neural circuits engaged in ventral hippocampal modulation of dopamine function in medial prefrontal cortex and ventral striatum

2008 ◽  
Vol 213 (1-2) ◽  
pp. 183-195 ◽  
Author(s):  
Pornnarin Taepavarapruk ◽  
John G. Howland ◽  
Soyon Ahn ◽  
Anthony G. Phillips
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ventral Striatum ◽  
Neural Circuits

Left and right 6-hydroxydopamine lesions of the medial prefrontal cortex differentially affect voluntary ethanol consumption

1999 ◽  
Vol 823 (1-2) ◽  
pp. 59-66 ◽  
Author(s):  
Darci M Nielsen ◽  
Kathleen J Crosley ◽  
Richard W Keller ◽  
Stanley D Glick ◽  
Jeffrey N Carlson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ethanol Consumption ◽  
Left And Right ◽  
6 Hydroxydopamine ◽  
Voluntary Ethanol Consumption

Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat

1995 ◽  
Vol 72 (1-2) ◽  
pp. 103-114 ◽  
Author(s):  
Peter Hertel ◽  
Jan M. Mathé ◽  
George G. Nomikos ◽  
Marina Iurlo ◽  
Aleksander A. Mathé ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ventral Striatum

Effect of ibotenic acid lesions of the medial prefrontal cortex on amphetamine-induced locomotion and regional brain catecholamine concentrations in the rat

1990 ◽  
Vol 534 (1-2) ◽  
pp. 263-272 ◽  
Author(s):  
George E. Jaskiw ◽  
Farouk Karoum ◽  
William J. Freed ◽  
Ingrid Phillips ◽  
Joel E. Kleinman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ibotenic Acid ◽  
Regional Brain

scholarly journals Corticotropin Releasing Factor Type 1 and 2 Receptor Signaling in the Medial Prefrontal Cortex Modulates Binge-Like Ethanol Consumption in C57BL/6J Mice

2019 ◽  
Vol 9 (7) ◽  
pp. 171 ◽  
Author(s):  
Stacey L. Robinson ◽  
Carlos A. Perez-Heydrich ◽  
Todd E. Thiele
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ethanol Consumption ◽  
Inhibitory Effect ◽  
Ethanol Intake ◽  
Corticotropin Releasing Factor ◽  
Factor Type ◽  
Drinking In The Dark

Corticotropin releasing factor (CRF) signaling via limbic CRF1 and 2 receptors (CRF1R and CRF2R, respectively) is known to modulate binge-like ethanol consumption in rodents. Though CRF signaling in the medial prefrontal cortex (mPFC) has been shown to modulate anxiety-like behavior and ethanol seeking, its role in binge ethanol intake is unknown. Here, we used “drinking-in-the-dark” (DID) procedures in male and female C57BL/6J mice to address this gap in the literature. First, the role of CRF1R and CRF2R signaling in the mPFC on ethanol consumption was evaluated through site-directed pharmacology. Next, we evaluated if CRF1R antagonist reduction of binge-intake was modulated in part through CRF2R activation by co-administration of a CRF1R and CRF2R antagonist. Intra-mPFC inhibition of CRF1R and activation of CRF2R resulted in decreased binge-like ethanol intake. Further, the inhibitory effect of the CRF1R antagonist was attenuated by co-administration of a CRF2R antagonist. We provide novel evidence that (1) inhibition of CRF1R or activation of CRF2R in the mPFC reduces binge-like ethanol intake; and (2) the effect of CRF1R antagonism may be mediated via enhanced CRF2R activation. These observations provide the first direct behavioral pharmacological evidence that CRF receptor activity in the mPFC modulates binge-like ethanol consumption.

Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice

2008 ◽  
Vol 54 (1) ◽  
pp. 108-116 ◽  
Author(s):  
David J. Rademacher ◽  
Sarah E. Meier ◽  
Leyu Shi ◽  
W.-S. Vanessa Ho ◽  
Abbas Jarrahian ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Restraint Stress ◽  
Ventral Striatum ◽  
Repeated Restraint Stress
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