Reactivity of the canine isolated internal mammary artery, saphenous vein, and coronary artery to constrictor and dilator substances: Relevance to coronary bypass graft surgery

1989 ◽  
Vol 3 (1) ◽  
pp. 128-129
Keyword(s):  
Coronary Artery ◽  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
Coronary Bypass Graft ◽  
Internal Mammary

Coronary artery bypass graft: why is the saphenous vein prone to intimal hyperplasia?

2014 ◽  
Vol 92 (7) ◽  
pp. 531-545 ◽  
Author(s):  
Swastika Sur ◽  
Jeffrey T. Sugimoto ◽  
Devendra K. Agrawal
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Internal Mammary

Proliferation and migration of smooth muscle cells and the resultant intimal hyperplasia cause coronary artery bypass graft failure. Both internal mammary artery and saphenous vein are the most commonly used bypass conduits. Although an internal mammary artery graft is immune to restenosis, a saphenous vein graft is prone to develop restenosis. We found significantly higher activity of phosphatase and tensin homolog (PTEN) in the smooth muscle cells of the internal mammary artery than in the saphenous vein. In this article, we critically review the pathophysiology of vein-graft failure with detailed discussion of the involvement of various factors, including PTEN, matrix metalloproteinases, and tissue inhibitor of metalloproteinases, in uncontrolled proliferation and migration of smooth muscle cells towards the lumen, and invasion of the graft conduit. We identified potential target sites that could be useful in preventing and (or) reversing unwanted consequences following coronary artery bypass graft using saphenous vein.

Pressure Increases Inert Particle Uptake in Human Saphenous Vein

2000 ◽  
Author(s):  
M. J. MacLennan ◽  
B. J. Leavitt ◽  
J. D. Schmoker ◽  
N. C. Chesler
Keyword(s):  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
The United States ◽  
Human Saphenous Vein ◽  
Particle Uptake ◽  
Internal Mammary

Abstract Cardiovascular disease is one of the leading causes of death in the United States, and coronary artery bypass graft surgery (CABG) is one of the mainstays of treatment for this disease (Niklason et al., 1999). Since artificial vascular grafts suitable for coronary bypass are not yet available, the autologous internal mammary artery (IMA) and saphenous vein are used to bypass diseased tissue (Niklason et al., 1999). While IMA grafts have high long-term patency rates, a saphenous vein grafted into the arterial position tends to stenose and eventually thrombose.

Biology of bypass vessels and their relation to patency and disease

2021 ◽  
pp. 23-30
Author(s):  
Thomas F. Lüscher
Keyword(s):  
Coronary Artery ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
Artery Bypass Graft ◽  
Bypass Grafts ◽  
Current Standard ◽  
Internal Mammary ◽  
The Right

Current standard surgical technique in patients undergoing coronary bypass grafting involves the use of an internal mammary artery (also known as an internal thoracic artery) bypass graft, in general to the left anterior descending coronary artery, and in many centres also the use of the right internal mammary artery to the right coronary artery. Several clinical studies have shown the superiority of mammary artery bypass grafts for survival of patients compared to the use of venous bypass grafts alone. Indeed, the internal mammary artery has several biological features, discussed in this chapter, that are remarkable and of great interest for biologists, cardiologists, and surgeons alike.

An Improved Technique for the Internal Mammary Artery Coronary Bypass Graft Procedure

1988 ◽  
Vol 3 (4) ◽  
pp. 467-473 ◽  
Author(s):  
VINCENT A. GAUDIANI ◽  
WALLY S. BUCH ◽  
ALBERT K. CHIN ◽  
LAURIE J. AYRES ◽  
THOMAS J. FOGARTY
Keyword(s):  
Internal Mammary Artery ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
Coronary Bypass Graft ◽  
Internal Mammary ◽  
Improved Technique

Pressure Increases Inert Particle Uptake in Human Saphenous Vein

2000 ◽  
Author(s):  
M. J. MacLennan ◽  
B. J. Leavitt ◽  
J. D. Schmoker ◽  
N. C. Chesler
Keyword(s):  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
The United States ◽  
Human Saphenous Vein ◽  
Particle Uptake ◽  
Internal Mammary

Abstract Cardiovascular disease is one of the leading causes of death in the United States, and coronary artery bypass graft surgery (CABG) is one of the mainstays of treatment for this disease [1]. Since artificial vascular grafts suitable for coronary bypass are not yet available, autologous internal mammary artery (IMA) and saphenous vein are used to bypass diseased tissue [1]. While IMA grafts have high long-term patency rates, saphenous vein grafted into the arterial position tends to stenose and eventually thrombose.

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