The ability of steroid hormones to control cAMP and cGMP production by human granulosa cells in culture

1995 ◽  
Vol 7 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Alexander V. Sirotkin ◽  
Jozef Mlynček ◽  
Jozef Lavrinčik ◽  
Jozef Bulla ◽  
Ladislav Hetenyi
Keyword(s):  
Steroid Hormones ◽  
Granulosa Cells ◽  
Cgmp Production ◽  
Human Granulosa Cells ◽  
Cells In Culture ◽  
Camp And Cgmp Production ◽  
Camp And Cgmp

Evidence for the production of a nonsteroidal endotheliotropic factor by human granulosa cells in culture*

1992 ◽  
Vol 57 (1) ◽  
pp. 107-112
Author(s):  
Eugene Katz ◽  
Arnold L. Goodman ◽  
Jairo García ◽  
Janice D. Rone
Keyword(s):  
Granulosa Cells ◽  
Human Granulosa Cells ◽  
Cells In Culture

scholarly journals Effects of Prolactin on Progestin Secretion by Human Granulosa Cells in Culture 1

1985 ◽  
Vol 32 (3) ◽  
pp. 541-545 ◽  
Author(s):  
Emiliano A. Soto ◽  
Richard W. Tureck ◽  
Jerome F. Strauss
Keyword(s):  
Granulosa Cells ◽  
Human Granulosa Cells ◽  
Cells In Culture

Effect of clomiphene cirate on oestrogen secretion by human granulosa cells in culture

1990 ◽  
Vol 5 (5) ◽  
pp. 533-536
Author(s):  
I. Bussenot ◽  
J. Parinaud ◽  
C. Clamagirand ◽  
G. Vieitez ◽  
G. Pontonnier
Keyword(s):  
Granulosa Cells ◽  
Human Granulosa Cells ◽  
Cells In Culture

Intracellular pH on adrenergic-stimulated cAMP and cGMP production in rat pinealocytes

1991 ◽  
Vol 261 (4) ◽  
pp. C642-C649 ◽  
Author(s):  
A. K. Ho ◽  
M. Girard ◽  
I. Young ◽  
C. L. Chik
Keyword(s):  
Intracellular Ph ◽  
Ammonium Chloride ◽  
Adrenergic Receptors ◽  
Sodium Propionate ◽  
Adrenergic Regulation ◽  
Cyclic Monophosphate ◽  
Cgmp Production ◽  
Camp And Cgmp Production ◽  
Camp And Cgmp

In rat pinealocytes, activation of alpha 1-adrenergic receptors leads to increases in intracellular pH (pHi). In this study, the role of pHi on adrenergic regulation of cyclic nucleotide accumulation was investigated using ammonium chloride, which increased pHi, and sodium propionate, which reduced pHi. Ammonium chloride significantly enhanced the norepinephrine-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) responses, while it selectively potentiated the isoproterenol (ISO)-stimulated cGMP response. Reduction of pHi by sodium propionate reduced the norepinephrine-stimulated cGMP accumulation by 70%, and its effect on the ISO-stimulated cGMP response was stimulatory. Treatment with sodium propionate effectively neutralized the enhancing effects of ammonium chloride on the adrenergic-stimulated cAMP and cGMP responses. These effects of sodium propionate and ammonium chloride on cyclic nucleotides appeared to reflect altered rate of synthesis, and they were also in part secondary to changes in intracellular Ca2+. Our findings indicate that the receptor-mediated changes in pHi may play an integral part in the adrenergic regulation of cAMP and cGMP production in rat pinealocytes.

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