Increasing telomerase enhanced steroidogenic genes expression and steroid hormones production in rat and human granulosa cells and in mouse ovary

2020 ◽  
Vol 197 ◽  
pp. 105551
Author(s):  
Amitai Mordechai ◽  
Michal Wasserman ◽  
Marina Abramov ◽  
David Ben-Menahem ◽  
Iris Har-Vardi ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Granulosa Cells ◽  
Mouse Ovary ◽  
Human Granulosa Cells ◽  
Genes Expression ◽  
Steroidogenic Genes

RELATIONSHIP BETWEEN THE ENDOCRINE ENVIRONMENT WITHIN THE GRAAFIAN FOLLICLE AND THE SUBSEQUENT RATE OF PROGESTERONE SECRETION BY HUMAN GRANULOSA CELLS IN VITRO

1975 ◽  
Vol 66 (3) ◽  
pp. 391-400 ◽  
Author(s):  
K. P. McNATTY ◽  
R. S. SAWERS
Keyword(s):  
Steroid Hormones ◽  
Mitotic Activity ◽  
Granulosa Cells ◽  
Follicular Development ◽  
Human Granulosa Cells ◽  
Long Period ◽  
Progesterone Secretion ◽  
Graafian Follicle ◽  
High Concentrations

SUMMARY The steroidogenic potential of granulosa cells harvested from human Graafian follicles containing varying concentrations of pituitary and steroid hormones was examined. The mitotic activity and production of progesterone by granulosa cells in vitro was found to be correlated with their hormonal environment at the time of harvesting. Only cells from follicles containing some FSH and high concentrations of oestradiol underwent spontaneous mitosis in vitro. However, mitosis could be induced by adding FSH and high concentrations of oestradiol to the culture, provided that the concentration of LH was low. Cells harvested from follicles containing LH, FSH and high concentrations of oestradiol secreted significantly more progesterone than cells from follicles which did not contain all three hormones. It is suggested that after the initiation of follicular development by FSH, a long period of exposure (8–10 days) to both FSH and oestradiol is necessary before the maximum biosynthetic capacity of granulosa cells is achieved; this synthetic potential is then only realized under the influence of LH and prolactin. Premature exposure to LH inhibits both the mitotic activity and the steroidogenic potential of these cells.

The ability of steroid hormones to control cAMP and cGMP production by human granulosa cells in culture

1995 ◽  
Vol 7 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Alexander V. Sirotkin ◽  
Jozef Mlynček ◽  
Jozef Lavrinčik ◽  
Jozef Bulla ◽  
Ladislav Hetenyi
Keyword(s):  
Steroid Hormones ◽  
Granulosa Cells ◽  
Cgmp Production ◽  
Human Granulosa Cells ◽  
Cells In Culture ◽  
Camp And Cgmp Production ◽  
Camp And Cgmp

Regulatory effect of vasopressin and its analogs on the steroidogenesis of human granulosa cells (GC) in vitro

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S183-S185
Author(s):  
H. MUELLER ◽  
T. RABE ◽  
B. HAUFF ◽  
L. KIESEL ◽  
B. RUNNEBAUM
Keyword(s):  
Granulosa Cells ◽  
Regulatory Effect ◽  
Human Granulosa Cells

0214 FSH dependent and IGF-1 independent phosphorylation of β-catenin is similar in bovine and human granulosa cells

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 101-101
Author(s):  
C. R. Smith ◽  
B. H. Aloqaily ◽  
C. A. Gifford ◽  
B. I. Gomez ◽  
J. A. Hernandez Gifford
Keyword(s):  
Granulosa Cells ◽  
Human Granulosa Cells
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