Modulation of affinity and density of LTB4 receptors on guinea pig lung membranes by divalent cations and guanine nucleotides

1991 ◽  
Vol 206 (4) ◽  
pp. 333-338 ◽  
Author(s):  
Ron C. Falcone ◽  
David Aharony
Keyword(s):  
Guinea Pig ◽  
Divalent Cations ◽  
Guanine Nucleotides

scholarly journals Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladder

1995 ◽  
Vol 114 (3) ◽  
pp. 632-639 ◽  
Author(s):  
Airat U. Ziganshin ◽  
Lilia E. Ziganshina ◽  
Charles H.V. Hoyle ◽  
Geoffrey Burnstock
Keyword(s):  
Urinary Bladder ◽  
Guinea Pig ◽  
Atpase Activity ◽  
Divalent Cations

scholarly journals STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA

1959 ◽  
Vol 110 (2) ◽  
pp. 311-339 ◽  
Author(s):  
Abraham G. Osler ◽  
Harry G. Randall ◽  
Betsy M. Hill ◽  
Zoltan Ovary
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Equivalence Ratio ◽  
Capillary Permeability ◽  
Divalent Cations ◽  
Biological Activities ◽  
Smooth Muscle Contraction ◽  
Immune Aggregates ◽  
Antigen Antibody ◽  
Pig Serum

The interaction of fresh rat and guinea pig serum with washed preformed immune aggregates has been studied with respect to the loss in hemolytic potency of the serum, diminution of the C'3; activity, and appearance of anaphylatoxin. It has been found that the formation of anaphylatoxin, as judged by its effect on capillary permeability and smooth muscle contraction, is coincident with or subsequent to the fixation of all the known C' components. Less anaphylatoxin is formed by aggregates formed with excess antigen than those in equivalence ratio combination. C' fixation, as well as anaphylatoxin production, may be inhibited by chelation of the divalent cations, presumably by interfering with the fixation of C'1, C'4, and C'2. Phlorizin suppresses the utilization of C'3 in immune hemolysis, C' fixation by antigen-antibody aggregates, and the production of anaphylatoxin. The biological activities associated with the fixation of C' are not manifest unless C'3 participates in this process at 37°C. It is concluded that the formation of anaphylatoxin may be regarded as a product of C' fixation.

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