Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat

1993 ◽  
Vol 245 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Osvaldo Giorgi ◽  
Maria G. Pibiri ◽  
Roberto Loi ◽  
Maria G. Corda
Keyword(s):  
Production Rate ◽  
Chronic Treatment ◽  
Sch 23390 ◽  
D1 Receptors ◽  
Dopamine D1 Receptors ◽  
Striatal System

Dopamine D1-Receptors Modulate Lateral Inhibition Between Principal Cells of the Nucleus Accumbens

2005 ◽  
Vol 93 (3) ◽  
pp. 1816-1819 ◽  
Author(s):  
Stefano Taverna ◽  
Barbara Canciani ◽  
Cyriel M. A. Pennartz
Keyword(s):  
Nucleus Accumbens ◽  
Sch 23390 ◽  
Brain Slices ◽  
D1 Receptor ◽  
D1 Receptors ◽  
Projection Neurons ◽  
Dopamine D1 Receptors ◽  
Principal Cells ◽  
Rat Nucleus Accumbens ◽  
Selection Of

One of the current hypotheses on dopamine in the physiology of motivation posits that this neurotransmitter regulates filtering and selection of inputs to the nucleus accumbens. The effects of dopamine (100 μM) and the D1-receptor agonist SKF 38393 (20–50 μM) on GABAergic synaptic transmission between pairs of principal cells of rat nucleus accumbens were studied by using simultaneous dual patch-clamp recordings in acutely prepared brain slices. Both compounds attenuated postsynaptic responses induced by presynaptic firing and this effect was reversed by the D1-receptor antagonist SCH 23390 (25 μM). This attenuating effect of dopamine D1-receptors may act to diminish competitive interactions between single projection neurons or ensembles in the nucleus accumbens.

Specific binding of 3H-SCH 23390 to dopamine D1 receptors

Life Sciences ◽  
1986 ◽  
Vol 38 (16) ◽  
pp. 1507-1514 ◽  
Author(s):  
Peter H. Andersen ◽  
Frederik C. Grønvald
Keyword(s):  
Specific Binding ◽  
Sch 23390 ◽  
D1 Receptors ◽  
Dopamine D1 Receptors

Neuroleptics cause stimulation of dopamine D1 receptors and their desensitization after chronic treatment

1994 ◽  
Vol 264 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Assunta Imperato ◽  
M.Carmen Obinu ◽  
Giovanna Carta ◽  
M.Stefania Mascia ◽  
M.Antonietta Casu ◽  
...  
Keyword(s):  
Chronic Treatment ◽  
D1 Receptors ◽  
Dopamine D1 Receptors ◽  
Stimulation Of

scholarly journals Dopamine D1 receptors characterized with [3H]SCH 23390. Solubilization of a guanine nucleotide-sensitive form of the receptor.

1986 ◽  
Vol 261 (18) ◽  
pp. 8397-8406
Author(s):  
H B Niznik ◽  
N Y Otsuka ◽  
A Dumbrille-Ross ◽  
D Grigoriadis ◽  
A Tirpak ◽  
...  
Keyword(s):  
Sch 23390 ◽  
D1 Receptors ◽  
Guanine Nucleotide ◽  
Dopamine D1 Receptors
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