Stimulation and inhibition of the pituitary-adrenal axis in depressed patients and control subjects

1991 ◽  
Vol 1 (3) ◽  
pp. 328-335
Author(s):  
C.C Gispen-De Wied ◽  
J.M Van Ree
1988 ◽  
Vol 18 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Alec Roy ◽  
Markku Linnoila ◽  
Farouk Karoum ◽  
David Pickar

SynopsisWe measured urinary outputs of urinary-free cortisol in 28 medication-free depressed patients and 32 normal controls. Depressed patients had significantly greater urinary outputs of urinary-free cortisol than controls. Also, there were significant correlations among depressed patients, but not among controls, between urinary-free cortisol and urinary outputs of norepinephrine and its metabolite vanillylmandelic acid (VMA). These urinary data extend recent findings suggesting that dysregulation of both the hypothalamic-pituitary-adrenal axis and noradrenergic system occur together in depression.


1988 ◽  
Vol 24 (6) ◽  
pp. 710-712 ◽  
Author(s):  
Kenneth L. Davis ◽  
Michael Davidson ◽  
Ren-Kui Yang ◽  
Bonnie M. Davis ◽  
Larry J. Siever ◽  
...  

2003 ◽  
Vol 17 (5) ◽  
pp. 365-372 ◽  
Author(s):  
Michael Irwin ◽  
Camellia Clark ◽  
Brian Kennedy ◽  
J Christian Gillin ◽  
Michael Ziegler

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