The role of state and trait anxiety in the processing of facial expressions of emotion

State anxiety appears to influence facial emotion processing (Attwood et al . 2017 R. Soc. Open Sci. 4 , 160855). We aimed to (i) replicate these findings and (ii) investigate the role of trait anxiety, in an experiment with healthy UK participants ( N = 48, 50% male, 50% high trait anxiety). High and low state anxiety were induced via inhalations of 7.5% carbon dioxide enriched air and medical air, respectively. High state anxiety reduced global emotion recognition accuracy ( p = 0.01, η p 2 = 0.14 ), but it did not affect interpretation bias towards perceiving anger in ambiguous angry–happy facial morphs ( p = 0.18, η p 2 = 0.04 ). We found no clear evidence of a relationship between trait anxiety and global emotion recognition accuracy ( p = 0.60, η p 2 = 0.01 ) or interpretation bias towards perceiving anger ( p = 0.83, η p 2 = 0.01 ). However, there was greater interpretation bias towards perceiving anger (i.e. away from happiness) during heightened state anxiety, among individuals with high trait anxiety ( p = 0.03, d z = 0.33). State anxiety appears to impair emotion recognition accuracy, and among individuals with high trait anxiety, it appears to increase biases towards perceiving anger (away from happiness). Trait anxiety alone does not appear to be associated with facial emotion processing.

Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study

Background: Microdoses of psychedelics (i.e. a sub-hallucinogenic dose taken every third day) can reduce symptoms of depression, anxiety and stress according to anecdotal reports and observational studies. Research with medium to high doses of psilocybin points towards potential underlying mechanisms, including the modulation of emotion and interoceptive processing. Aims: In this preregistered study, we investigated whether psilocybin microdoses alter self-reported interoceptive awareness and whether repeated microdosing over 3 weeks modulates emotion processing and reduces symptoms of anxiety and depression. Methods: We used a double-blind, placebo-controlled, within-subject crossover design. Participants completed the Multidimensional Assessment of Interoceptive Awareness Questionnaire 1½ h after self-administering their second dose (or placebo), and the emotional go/no-go task and the shortened Depression Anxiety Stress Scale 1½ h after self-administering their seventh dose. Results: Our confirmatory analyses revealed that psilocybin microdosing did not affect emotion processing or symptoms of anxiety and depression compared with placebo. Our exploratory analyses revealed that psilocybin microdosing did not affect self-reported interoceptive awareness, that symptoms of depression and stress were significantly reduced in the first block compared with baseline, that participants broke blind in the second block and that there was no effect of expectations. Further research in a substance-naïve population with clinical range anxiety and depressive symptoms is needed to substantiate the potential beneficial effects of microdosing.

A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing

A topic of interest is the way decoding and interpreting facial emotional expressions can lead to mutual understanding. Facial emotional expression is a basic source of information that guarantees the functioning of other higher cognitive processes (e.g., empathy, cooperativity, prosociality, or decision-making, among others). In this regard, hormones such as oxytocin, cortisol, and/or testosterone have been found to be important in modifying facial emotion processing. In fact, brain structures that participate in facial emotion processing have been shown to be rich in receptors for these hormones. Nonetheless, much of this research has been based on correlational designs. In recent years, a growing number of researchers have tried to carry out controlled laboratory manipulation of these hormones by administering synthetic forms of these hormones. The main objective of this study was to carry out a systematic review of studies that assess whether manipulation of these three hormones effectively promotes significant alterations in facial emotional processing. To carry out this review, PRISMA quality criteria for reviews were followed, using the following digital databases: PsycINFO, PubMed, Dialnet, Psicodoc, Web of Knowledge, and the Cochrane Library, and focusing on manuscripts with a robust research design (e.g., randomized, single- or double-blind, and/or placebo-controlled) to increase the value of this systematic review. An initial identification of 6340 abstracts and retrieval of 910 full texts led to the final inclusion of 101 papers that met all the inclusion criteria. Only about 18% of the manuscripts included reported a direct effect of hormone manipulation. In fact, emotional accuracy seemed to be enhanced after oxytocin increases, but it diminished when cortisol and/or testosterone increased. Nonetheless, when emotional valence and participants’ gender were included, hormonal manipulation reached significance (in around 53% of the articles). In fact, these studies offered a heterogeneous pattern in the way these hormones altered speed processing, attention, and memory. This study reinforces the idea that these hormones are important, but not the main modulators of facial emotion processing. As our comprehension of hormonal effects on emotional processing improves, the potential to design good treatments to improve this ability will be greater.

Mindfulness Meditation Improves Musical Aesthetic Emotion Processing in Young Adults

This study explored the behavioral and neural correlates of mindfulness meditation improvement in musical aesthetic emotion processing (MAEP) in young adults, using the revised across-modal priming paradigm. Sixty-two participants were selected from 652 college students who assessed their mindfulness traits using the Mindful Attention Awareness Scale (MAAS). According to the 27% ratio of the high and low total scores, participants were divided into two subgroups: high trait group (n =31) and low trait group (n =31). Participants underwent facial recognition and emotional arousal tasks while listening to music, and simultaneously recorded event-related potentials (ERPs). The N400, P3, and late positive component (LPC) were investigated. The behavioral results showed that mindfulness meditation improved executive control abilities in emotional face processing and effectively regulated the emotional arousal of repeated listening to familiar music among young adults. These improvements were associated with positive changes in key neural signatures of facial recognition (smaller P3 and larger LPC effects) and emotional arousal (smaller N400 and larger LPC effects). Our results show that P3, N400, and LPC are important neural markers for the improvement of executive control and regulating emotional arousal in musical aesthetic emotion processing, providing new evidence for exploring attention training and emotional processing. We revised the affecting priming paradigm and E-prime 3.0 procedure to fulfill the simultaneous measurement of music listening and experimental tasks and provide a new experimental paradigm to simultaneously detect the behavioral and neural correlates of mindfulness-based musical aesthetic processing.

Minority Stress and the Effects on Emotion Processing in Transgender Men and Cisgender People: A Study Combining fMRI and Proton Magnetic Resonance Spectroscopy ( 1H-MRS)

Background Minority stress via discrimination, stigmatization, and exposure to violence can lead to development of mood and anxiety disorders and underlying neurobiochemical changes. To date, the neural and neurochemical correlates of emotion processing in transgender people (and their interaction) are unknown. Methods This study combined functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy ( 1H-MRS) to uncover the effects of anxiety and perceived stress on the neural and neurochemical substrates, specifically Choline, on emotion processing in transgender men. Thirty transgender men (TM), 30 cisgender men (CM), and 35 cisgender women (CW) passively viewed angry, neutral, happy, and surprise faces in the fMRI scanner, underwent a 1H-MRS scan and filled out mood and anxiety related questionnaires. Results As predicted, Choline levels modulated the relationship between anxiety and stress symptoms and the neural response to angry and surprise (but not happy faces) in the amygdala. This was only the case for TM but not cisgender comparisons. More generally, neural responses in the left amygdala, left middle frontal gyrus, and medial frontal gyrus to emotional faces in TM resembled that of CW. Conclusions These results provide first evidence of a critical interaction between levels of analysis and that Choline may influence neural processing of emotion in individuals prone to minority stress.