Important role of mucociliary system in otitis media with effusion

1994 ◽  
Vol 1 ◽  
pp. 279
Author(s):  
Y. Ohno ◽  
Y. Ohashi ◽  
Y. Sugiura ◽  
H. Okamoto ◽  
Y. Kakinoki ◽  
...  
2021 ◽  
pp. 019459982098745
Author(s):  
Mirko Aldè ◽  
Federica Di Berardino ◽  
Paola Marchisio ◽  
Giovanna Cantarella ◽  
Umberto Ambrosetti ◽  
...  

Objective To evaluate the role of social isolation during the lockdown due to the SARS-CoV-2 outbreak (severe acute respiratory syndrome coronavirus 2) in modifying the prevalence of otitis media with effusion (OME) and the natural history of chronic OME. Study Design Retrospective study. Setting Tertiary level referral audiologic center. Methods We assessed the prevalence of OME among children aged 6 months to 12 years who attended the outpatient clinic for hearing or vestibular disorders during 2 periods before the lockdown, May-June 2019 (n = 350) and January-February 2020 (n = 366), and the period immediately after the lockdown, May-June 2020 (n = 216). We also compared the disease resolution rates between a subgroup of children with chronic OME (n = 30) who were diagnosed in summer 2019 and reevaluated in May-June 2020 and a similar subgroup (n = 29) assessed in 2018-2019. Results The prevalence of OME in this clinic population was 40.6% in May-June 2019, 52.2% in January-February 2020, and 2.3% in May-June 2020. Children with chronic OME had a higher rate of disease resolution in May-June 2020 (93.3%) than those examined in May-June 2019 (20.7%, P < .001). Conclusion Closure of schools and the physical distancing rules were correlated with a reduction in the prevalence of OME and favored the resolution of its chronic forms among children who attended the outpatient clinic. These data could suggest that in the presence of chronic OME, keeping young children out of group care settings for a period might be beneficial to allow for OME resolution.


2001 ◽  
Vol 110 (6) ◽  
pp. 574-580 ◽  
Author(s):  
Tetsuo Watanabe ◽  
Takashi Hirano ◽  
Yuichi Kurono ◽  
Masashi Suzuki ◽  
Goro Mogi

1978 ◽  
Vol 86 (2) ◽  
pp. ORL-258-ORL-268 ◽  
Author(s):  
Joseph Mravec ◽  
Daniel M. Lewis ◽  
David J. Lim

The possibility that immune complexes cause otitis media with effusion (OME) has been previously proposed. In order to test this hypothesis we developed an animal model in which immune complexes were injected into the middle ears of chinchillas and the animals killed at various time intervals thereafter. Moderate inflammatory changes were seen in animals killed four hours postinjection, whereas intense inflammation was observed in those killed at 24 hours. Inflammatory changes observed included capillary dilatation with increased capillary permeability, migration of polymorphonuclear leukocytes into the submucosa, hemorrhage, and damage to and actual disruption of the subepithelial basement membrane. These changes are consistent with a complement-mediated acute inflammatory reaction. Although no definite conclusion can be made concerning the etiologic role of immune complex in OME, our findings show that immune complexes can cause acute inflammatory changes in the middle ear of the experimental animal.


2004 ◽  
Vol 68 (7) ◽  
pp. 889-894 ◽  
Author(s):  
Murat Yariktas ◽  
Fehmi Doner ◽  
Harun Dogru ◽  
Hasan Yasan ◽  
Namik Delibas

1982 ◽  
Vol 90 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Joel M. Bernstein ◽  
Diane Dryja ◽  
Erwin Neter

Twenty-eight middle ear effusions from 27 patients with chronic otitis media with effusion were studied for the presence of bacteria. The most common isolates were coagulase-negative staphylococci. However, biochemical and antibiotic sensitivity patterns demonstrated that these organisms represented a heterogenous group. At least three subtypes of coagulase-negative staphylococci were identified from the middle ear effusions, and in only one instance was the isolate from the ear canal identical with that of the middle ear effusion. The data presented suggest that coagulase-negative staphylococci from the middle ear effusions may not be contaminants; however, it cannot be determined from this study whether these organisms play a role as pathogens or as the result of indolent colonization.


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