Protein tyrosine kinases in the initiation of antigen receptor signaling

1995 ◽  
Vol 7 (3) ◽  
pp. 306-311 ◽  
Author(s):  
J Bolen
Keyword(s):  
Tyrosine Kinases ◽  
Antigen Receptor ◽  
Protein Tyrosine Kinases ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
Antigen Receptor Signaling

scholarly journals Disruption of Lymphocyte Function and Signaling in CD45–associated Protein–null Mice

1998 ◽  
Vol 187 (11) ◽  
pp. 1863-1870 ◽  
Author(s):  
Akio Matsuda ◽  
Satoshi Motoya ◽  
Shioko Kimura ◽  
Renee McInnis ◽  
Abby L. Maizel ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Kinases ◽  
Tyrosine Phosphatase ◽  
Antigen Receptor ◽  
Lymphocyte Function ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
Antigen Receptor Signaling

CD45-AP specifically associates with CD45, a protein tyrosine phosphatase essential for lymphocyte differentiation and antigen receptor–mediated signal transduction. CD45 is thought to mediate antigen receptor signaling by dephosphorylating regulatory tyrosine residues on Src family protein tyrosine kinases such as Lck. However, the mechanism for regulating CD45 protein tyrosine phosphatase activity remains unclear. CD45-AP–null mice were created to examine the role of CD45-AP in CD45-mediated signal transduction. T and B lymphocytes showed reduced proliferation in response to antigen receptor stimulation. Both mixed leukocyte reaction and cytotoxic T lymphocyte functions of T cells were also markedly decreased in CD45-AP–null mice. Interestingly, the interaction between CD45 and Lck was significantly reduced in CD45-AP–null T cells, indicating that CD45-AP directly or indirectly mediates the interaction of CD45 with Lck. Our data indicate that CD45-AP is required for normal antigen receptor signaling and function in lymphocytes.

scholarly journals Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 ◽  
Vol 272 (18) ◽  
pp. 11674-11677 ◽  
Author(s):  
Michael A. Musci ◽  
L. Ranee Hendricks-Taylor ◽  
David G. Motto ◽  
Michael Paskind ◽  
Joanne Kamens ◽  
...  
Keyword(s):  
T Cell ◽  
Molecular Cloning ◽  
Tyrosine Kinases ◽  
Antigen Receptor ◽  
Protein Tyrosine Kinases ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Protein Tyrosine ◽  
Cell Antigen

scholarly journals Regulation of antigen receptor function by protein tyrosine kinases

1999 ◽  
Vol 71 (3-4) ◽  
pp. 373-392 ◽  
Author(s):  
Juliane Bubeck-Wardenburg ◽  
Jane Wong ◽  
Klaus Fütterer ◽  
Rajita Pappu ◽  
Chong Fu ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Antigen Receptor ◽  
Protein Tyrosine Kinases ◽  
Receptor Function ◽  
Protein Tyrosine

scholarly journals Interaction between CD45-AP and Protein-tyrosine Kinases Involved in T Cell Receptor Signaling

1999 ◽  
Vol 274 (3) ◽  
pp. 1407-1414 ◽  
Author(s):  
Satoshi Motoya ◽  
Koichi Kitamura ◽  
Akio Matsuda ◽  
Abby L. Maizel ◽  
Hiroyuki Yamamoto ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Cell Receptor ◽  
Protein Tyrosine Kinases ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling
Sign in / Sign up

Export Citation Format

Share Document