Synthesis and evaluation of 1-{1-[5-(2′-[18F]Fluoroethyl)-2-thienyl]-cyclohexyl}piperidine as a potential in vivo radioligand for the NMDA receptor—Channel complex

1993 ◽  
Vol 20 (7) ◽  
pp. 865-873 ◽  
Author(s):  
Kazuhiro Orita ◽  
Shigeki Sasaki ◽  
Minoru Maeda ◽  
Atsushi Hashimoto ◽  
Toru Nishikawa ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Channel ◽  
Receptor Channel

In vivo labelling of the NMDA receptor channel complex by [3H]MK-801

1988 ◽  
Vol 158 (3) ◽  
pp. 279-282 ◽  
Author(s):  
Gary W. Price ◽  
Randy G. Ahier ◽  
Derek N. Middlemiss ◽  
Lakhbir Singh ◽  
Mark D. Tricklebank ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Mk 801 ◽  
In Vivo Labelling ◽  
Nmda Receptor Channel ◽  
Receptor Channel

In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers

2013 ◽  
Vol 23 (13) ◽  
pp. 3901-3904 ◽  
Author(s):  
Ryotaro Saiki ◽  
Yuki Yoshizawa ◽  
Anna Minarini ◽  
Andrea Milelli ◽  
Chiara Marchetti ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Channel Blockers ◽  
In Vivo Evaluation ◽  
Nmda Receptor Channel ◽  
Receptor Channel

NF-κB induction during in vivo hypoxia in dorsocaudal brain stem of rat: effect of MK-801 andl-NAME

1998 ◽  
Vol 85 (1) ◽  
pp. 372-376 ◽  
Author(s):  
Evelyne Gozal ◽  
Narong Simakajornboon ◽  
David Gozal
Keyword(s):  
Nmda Receptor ◽  
Brain Stem ◽  
Receptor Activation ◽  
Hypoxic Ventilatory Response ◽  
Mk 801 ◽  
Oxide Synthase ◽  
Nmda Receptor Channel ◽  
Nmda Receptor Activation ◽  
Receptor Channel

In the nucleus of the solitary tract, NMDA receptors are critical for the hypoxic ventilatory response while neuronal nitric oxide synthase (NOS) modulates the late component of this response. Nuclear factor (NF)-κB is a ubiquitous transcription factor that increases the expression of multiple stress-activated genes. We sought to examine temporal changes in expression of NF-κB within the dorsocaudal brain stem of conscious rats after exposures to 10% O2. Time-dependent increases in NF-κB occurred with hypoxia and peaked at 60 min. Pretreatment with the N-methyl-d-aspartate (NMDA)-receptor channel antagonist dizocilpine maleate (MK-801) markedly attenuated NF-κB complexes during hypoxia. In contrast, after NOS inhibition with N G-nitro-l-arginine methyl ester (l-NAME), although NF-κB was diminished in normoxia, increased NF-κB expression still occurred with hypoxia. Increased phosphorylation of the NF-κB regulatory unit [inhibitory (I)κB] was detected by immunoblotting and also peaked at 60 min. Phosphorylation of Iκ-B during hypoxia was attenuated by MK-801 but not byl-NAME. Thus NMDA-receptor activation in the dorsocaudal brain stem during hypoxia elicits in NF-κB activity marked enhancements that are unaffected after NOS blockade.

Effect of NMDA receptor channel blockade on aggression in isolated male mice

1998 ◽  
Author(s):  
Irina Belozertseva ◽  
Anton Bespalov ◽  
Eugeny Gmiro ◽  
Wojciech Danysz ◽  
Edwin Zvartau
Keyword(s):  
Nmda Receptor ◽  
Male Mice ◽  
Channel Blockade ◽  
Nmda Receptor Channel ◽  
Receptor Channel

Neuroprotection by novel antagonists at the NMDA receptor channel and glycineB sites

1998 ◽  
Vol 347 (2-3) ◽  
pp. 183-187 ◽  
Author(s):  
Gary L Wenk ◽  
Lauren M Baker ◽  
James D Stoehr ◽  
Beatrice Hauss-Wegrzyniak ◽  
Wojciech Danysz
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Channel ◽  
Receptor Channel
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