GENETIC REGULATION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION BY CHEMICAL CARCINOGENS AND OTHER ENVIRONMENTAL POLLUTANTS

Abstracts ◽  
1978 ◽  
pp. 422
Author(s):  
Daniel W. Nebert ◽  
Ida S. Owens ◽  
Itsu Kano ◽  
Thomas M. Guenthner
Keyword(s):  
Genetic Regulation ◽  
Environmental Pollutants ◽  
Aryl Hydrocarbon Hydroxylase ◽  
Chemical Carcinogens ◽  
Aryl Hydrocarbon

scholarly journals Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

1972 ◽  
Vol 247 (4) ◽  
pp. 1125-1137 ◽  
Author(s):  
Jacques E. Gielen ◽  
Francine M. Goujon ◽  
Daniel W. Nebert
Keyword(s):  
Genetic Regulation ◽  
Aryl Hydrocarbon Hydroxylase ◽  
Aryl Hydrocarbon

scholarly journals Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 60
Author(s):  
Anne Stinn ◽  
Jens Furkert ◽  
Stefan H. E. Kaufmann ◽  
Pedro Moura-Alves ◽  
Michael Kolbe
Keyword(s):  
Ligand Binding ◽  
Environmental Pollutants ◽  
Screening Strategy ◽  
Pharmacological Intervention ◽  
Binding Affinities ◽  
Free System ◽  
Microscale Thermophoresis ◽  
Aryl Hydrocarbon ◽  
Promising Target ◽  
A Cell

The aryl hydrocarbon receptor (AhR) is a highly conserved cellular sensor of a variety of environmental pollutants and dietary-, cell- and microbiota-derived metabolites with important roles in fundamental biological processes. Deregulation of the AhR pathway is implicated in several diseases, including autoimmune diseases and cancer, rendering AhR a promising target for drug development and host-directed therapy. The pharmacological intervention of AhR processes requires detailed information about the ligand binding properties to allow specific targeting of a particular signaling process without affecting the remaining. Here, we present a novel microscale thermophoresis-based approach to monitoring the binding of purified recombinant human AhR to its natural ligands in a cell-free system. This approach facilitates a precise identification and characterization of unknown AhR ligands and represents a screening strategy for the discovery of potential selective AhR modulators.

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