MICROREGIONAL HETEROGENEITY IN TUMOUR PERFUSION

1992 ◽  
pp. 762-767
Author(s):  
Martin J. Trotter ◽  
David J. Chaplin
Keyword(s):  
Tumour Perfusion

Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice

1993 ◽  
Vol 28 (3) ◽  
pp. 208-218 ◽  
Author(s):  
Davina J. Honess ◽  
Ian F. Dennis ◽  
Norman M. Bleehen
Keyword(s):  
Tumour Perfusion

scholarly journals Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

2019 ◽  
Vol 11 (12) ◽  
Author(s):  
Yen Ling Yeow ◽  
Venkata Ramana Kotamraju ◽  
Xiao Wang ◽  
Meenu Chopra ◽  
Nasibah Azme ◽  
...  
Keyword(s):  
Tumour Perfusion ◽  
Immune Mediated

Visualizing tumour perfusion with plane-wave contrast-enhanced Doppler: Concepts and trade-offs

2015 ◽  
Author(s):  
Charles Tremblay-Darveau ◽  
Ross Williams ◽  
Paul S. Sheeran ◽  
Laurent Milot ◽  
Matthew Bruce ◽  
...  
Keyword(s):  
Plane Wave ◽  
Tumour Perfusion ◽  
Trade Offs ◽  
Contrast Enhanced

Tumour perfusion assessment during regional hyperthermia treatment: Comparison of temperature probe measurement with H215O-PET perfusion

2010 ◽  
Vol 26 (4) ◽  
pp. 404-411 ◽  
Author(s):  
Chi-Hee Cho ◽  
Geetha Sreenivasa ◽  
Michail Plotkin ◽  
Hubertus Pietsch ◽  
Peter Wust ◽  
...  
Keyword(s):  
Probe Measurement ◽  
Hyperthermia Treatment ◽  
Regional Hyperthermia ◽  
Treatment Comparison ◽  
Temperature Probe ◽  
Tumour Perfusion ◽  
Perfusion Assessment ◽  
H215o Pet

Pentoxifylline Increases Rif-1 Tumour pO2in a Manner Compatible with its Ability to Increase Relative Tumour Perfusion

1995 ◽  
Vol 34 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Davina J. Honess ◽  
Mark S. Andrews ◽  
Rose Ward ◽  
Norman M. Bleehen
Keyword(s):  
Tumour Perfusion

scholarly journals Pharmacodynamic analysis of tumour perfusion assessed by 15O-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

2012 ◽  
Vol 2 (1) ◽  
pp. 31 ◽  
Author(s):  
Andrew M Scott ◽  
Paul L Mitchell ◽  
Graeme O'Keefe ◽  
Timothy Saunder ◽  
Rodney J Hicks ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Sunitinib Malate ◽  
Tumour Perfusion ◽  
Advanced Malignancies ◽  
Pharmacodynamic Analysis

scholarly journals Unified platform for multimodal voxel-based analysis to evaluate tumour perfusion and diffusion characteristics before and after radiation treatment evaluated in metastatic brain cancer

2019 ◽  
Vol 92 (1096) ◽  
pp. 20170461
Author(s):  
Catherine Coolens ◽  
Brandon Driscoll ◽  
Warren Foltz ◽  
Igor Svistoun ◽  
Noha Sinno ◽  
...  
Keyword(s):  
Brain Cancer ◽  
Radiation Treatment ◽  
Tumour Perfusion ◽  
Diffusion Characteristics ◽  
Before And After ◽  
And Diffusion

scholarly journals Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jessica Buck ◽  
James R. Larkin ◽  
Manon A. Simard ◽  
Alexandre A. Khrapitchev ◽  
Michael A. Chappell ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Blood Vessels ◽  
Arterial Spin Labelling ◽  
Resonance Imaging ◽  
Tumour Blood Flow ◽  
Tumour Perfusion ◽  
Tumour Blood

Brain and tumour blood flow can be measured noninvasively using arterial spin labelling (ASL) magnetic resonance imaging (MRI), but reliable quantification in mouse models remains difficult. Pseudocontinuous ASL (pCASL) is recommended as the clinical standard for ASL and can be improved using multiphase labelling (MP pCASL). The aim of this study was to optimise and validate MP pCASL MRI for cerebral blood flow (CBF) measurement in mice and to assess its sensitivity to tumour perfusion. Following optimization of the MP pCASL sequence, CBF data were compared with gold-standard autoradiography, showing close agreement. Subsequently, MP pCASL data were acquired at weekly intervals in models of primary and secondary brain tumours, and tumour microvessel density was determined histologically. MP pCASL measurements in a secondary brain tumour model revealed a significant reduction in blood flow at day 35 after induction, despite a higher density of blood vessels. Tumour core regions also showed reduced blood flow compared with the tumour rim. Similarly, significant reductions in CBF were found in a model of glioma 28 days after tumour induction, together with an increased density of blood vessels. These findings indicate that MP pCASL MRI provides accurate and robust measurements of cerebral blood flow in naïve mice and is sensitive to changes in tumour perfusion.

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