CALSEQUESTRIN121Supported by grants from the Medical Research Council of Canada (D.H.M.), the Heart and Stroke Foundation of Ontario (D.H.M.), the Muscular Dystrophy Association of Canada (D.H.M. and R.A.F.R.) and the Alberta Heritage Foundation for Medical Research (R.A.F.R and M.O.).2Present address: Membrane Biology Group, Department of Medicine, Room 7307, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8

Because of the necessity of objective instrumental methods for assessing the state of skeletal musculature in patients with Duchenne muscular dystrophy, the aim of our work was to evaluate the correlation between manual methods of assessment of the muscle strength and the results of magnetic resonance imaging (MRI) of the skeletal muscles of lower limbs. We have examined 15 corticosteroid-naive patients with Duchenne muscular dystrophy. Patients were divided into 2 groups: ambulant patients (average age 8.1 years) and non-ambulant patients (mean age 12.7 years). Muscle strength of lower extremities of all patients has been evaluated by Medical Research Council scale and MRI of skeletal muscles of the pelvic girdle, thighs and lower legs has been performed. The following results have been obtained: ambulant patients have been characterized by a high correlation of MRC scale and MRI of the lower extremities in the evaluation of the pelvic girdle and thighs muscles and the total score (pelvic girdle, thighs and lower legs) and salient correlation in the evaluation of the lower legs muscles. Non-ambulant patients have been characterized by moderate correlation in the evaluation of pelvic girdle and thighs muscles, as well as the total score of lower limbs. There was no correlation between MRC and MRI results in the muscles of the lower legs. Magnetic resonance tomography is able to reliably estimate the degree of fatty infiltration in Duchenne muscular dystrophy and is the method of choice in the diagnosis and evaluation of the severity of this disease.

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SOME RECENT PROGRESS IN NEURO-MUSCULAR SYSTEMS1)1)This work was supported by grants from the National Research Council of Canada to M. N. OĞuztöreli and the Medical Research Council and the Muscular Dystrophy Association of Canada to R. B. Stein.

Nonlinear Systems and Applications ◽

10.1016/b978-0-12-434150-0.50026-6 ◽

1977 ◽

pp. 257-293 ◽

Cited By ~ 1

Author(s):

M.N. OĞUZTÖRELI ◽

R.B. STEIN

Keyword(s):

Muscular Dystrophy ◽

Medical Research ◽

Recent Progress ◽

Research Council ◽

Medical Research Council ◽

National Research Council

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FREEZING OF MUSCLE FIBERS ULTRATHIN CRYOCUTTING AND TRANSFER OF FROZEN-HYDRATED SECTIONS**This work was carried out under grants from the Swedish Medical Research Council, the National Research Council of Italy, and the Muscular Dystrophy Association.

Microbeam Analysis in Biology ◽

10.1016/b978-0-12-440340-6.50031-5 ◽

1979 ◽

pp. 427-444 ◽

Cited By ~ 4

Author(s):

Michael Sjöström ◽

Ugo Valdrè

Keyword(s):

Muscular Dystrophy ◽

Medical Research ◽

Research Council ◽

Medical Research Council ◽

Muscle Fibers ◽

National Research Council ◽

Swedish Medical

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The Use of Non-Human Primates in Biological and Medical Research: Evidence Submitted by FRAME to the Academy of Medical Sciences/Medical Research Council/Royal Society/Wellcome Trust Working Group

Alternatives to Laboratory Animals ◽

10.1177/026119290503300501 ◽

2005 ◽

Vol 33 (5) ◽

pp. 519-527 ◽

Cited By ~ 4

Author(s):

Nirmala Bhogal ◽

Michelle Hudson ◽

Michael Balls ◽

Robert D. Combes

Keyword(s):

Medical Research ◽

Working Group ◽

Royal Society ◽

Research Council ◽

Medical Research Council ◽

Primate Research ◽

Medical Sciences ◽

Scientific Experts ◽

Overwhelming Evidence ◽

Fundamental Research

The Academy of Medical Sciences, the Medical Research Council, the Royal Society and the Wellcome Trust are undertaking a study into the use of non-human primates in biological and medical research. An independent working group of scientific experts, led by Sir David Weatherall, aims to produce a report summarising the findings of this study, early in 2006. The trends in primate research, and the nature and effects of recent and proposed changes in the global use of non-human primates in research, will be investigated. The associated ethical, welfare and regulatory issues, and the role and impact of the Three Rs principles of refinement, reduction and replacement will also be reviewed. As part of this study, a call for evidence was made. The evidence submitted by FRAME emphasised that the use of non-human primates for fundamental research or for regulatory testing still fails to take into account the fact that, although non-human primates are anatomically and physiologically similar to humans, they are not necessarily relevant models for studies on human disease or human physiology. FRAME continues to believe that we have a duty to ensure that these animals are not used without overwhelming evidence that they are the only suitable and relevant models for use in work of undeniable significance.

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