Genetics and Vascular Biology of Brain Vascular Malformations

Stroke ◽  
2022 ◽  
pp. 138-152.e8
Author(s):  
Helen Kim ◽  
Ludmila Pawlikowska ◽  
Hua Su
Stroke ◽  
2016 ◽  
pp. 149-162.e7 ◽  
Author(s):  
Helen Kim ◽  
Ludmila Pawlikowska ◽  
Hua Su ◽  
William L. Young

Stroke ◽  
2011 ◽  
pp. 169-186 ◽  
Author(s):  
Helen Kim ◽  
Ludmila Pawlikowska ◽  
William L. Young

VASA ◽  
2014 ◽  
Vol 43 (5) ◽  
pp. 390-394
Author(s):  
Yu-Ching Lin ◽  
Yu-Hsiang Juan ◽  
Jennifer N. Mhuircheartaigh ◽  
Ting-Wen Sheng ◽  
Sachin S. Saboo ◽  
...  

Phlebologie ◽  
2010 ◽  
Vol 39 (03) ◽  
pp. 167-175
Author(s):  
M. Poetke ◽  
P. Urban ◽  
H.-P. Berlien

SummaryVascular malformations are structural abnormalities, errors of vascular morphogenesis, which can be localized in all parts of the vascular system. All vascular malformations by definition, are present at birth and grow proportionately with the child; their volume can change. In contrast to the haemangiomas, which only proliferate from the endothelial cells the division in stages is of clinical importance. Vascular malformations are divided from the part of vascular system, which is affected.In principle the techniques of laser application in congenital vascular tumours like haemangiomas and in vascular malformations are similar, but the aim is different. In tumours the aim is to induce regression, in vascular malformations the aim is to destroy the pathologic vascular structure because there is no spontaneous regression. This means that the parameters for treatment of vascular malformations must be more aggressive than for vascular tumours.


2018 ◽  
Author(s):  
Paolo Madeddu

The year 2018 marked the 110th anniversary of Goldmann’s discovery that vascularization is an active process in tissues1 and the 50th anniversary of the concomitant reports from Greenblatt and Shubik2 and Ehrmann and Knoth3 that soluble morphogenic factors are required for cancer angiogenesis. Many other radically transformative paradigms have been introduced in the last decades. To name a few, the molecular search for the identity of master regulators of vascular tone led to the discovery of the Endothelium-Derived Relaxing Factor (EDRF; i.e., NO4), while clinically inspired investigations led to the recognition of the pathophysiological relevance of neoangiogenesis in cancer and tissue healing. This brought about the proposal of blocking angiogenesis to halt tumor growth and stimulating angiogenesis to treat myocardial ischemia and heart failure5-7.


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