Abstract
Background: One-lung flooding (OLF) represents an ideal acoustic pathway for focused ultrasound ablation of lung tumours. Despite stabilization of the adjacent hemidiaphragm by OLF, standard pressure-controlled ventilation (PCV) of the contralateral lung causes an unacceptable movement of the flooded lung. We examined whether superimposed high-frequency jet ventilation (SHFJV) reduces lung motion compared to PCV during OLF.Methods: The study included 15 pigs: 10 underwent OLF; 5 controls underwent two-lung ventilation without OLF. Using ultrasound, diaphragm displacement on the flooded lung side was measured during PCV and SHFJV in the left lateral (LLP), supine (SP), and right lateral positions (RLP). Bronchus and mediastinum displacements were measured in the right lateral position. Results: Diaphragm displacement on the flooded lung side was significantly reduced during SHFJV, compared with PCV, in all animal positions (LLP: 7 mm [4.75–8.0] vs. 17 mm [14.75–19.0], P = 0.0039; SP: 4 mm [3.75–4.25] vs. 17 mm [16.0–18.5], P = 0.0039; RLP: 8 mm [5.75–9.0] vs. 20 mm [14.0–23.25], P = 0.0078). Displacement of both the bronchus and mediastinum were significantly reduced during SHFJV, compared with PCV, in RLP (bronchus: 2.0 mm [1.75–2.25] vs. 3.0 mm [2.75–3.0], P = 0.027; mediastinum: 4.5 mm [4.0–5.0] vs. 10 mm [7.0–10.0], P = 0.0078; Figs. 5, 6). Conclusion: Thus, SHFJV minimises diaphragm, bronchus, and mediastinum motion during OLF, which is a prerequisite for effective lung tumour ablation.
Effect of Open-Chest Surgery in the Lateral Position on Blood Propofol Concentration during Target-Controlled Infusion of Propofol
