A 25-Year-Old Woman from Egypt With Severe Chronic Diarrhoea and Malabsorption

Author(s):  
Thomas Weitzel ◽  
Nadia El-Dib
Keyword(s):  
2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Patricia Maeve Ward ◽  
Gerard McLauchlan ◽  
Caroline Millins ◽  
Dermot Mullen ◽  
Alix Rebecca McBrearty
Keyword(s):  

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Jing Ruan ◽  
Xuan Wang ◽  
Xianyong Jiang ◽  
Miao Chen

Abstract Background Pure red cell aplasia (PRCA) and large granular lymphocytic leukaemia (LGLL) are very rare complications of autoimmune polyendocrine syndrome type 1 (APS1). Here, we report a case of APS1 with PRCA and LGLL. Previous cases were reviewed, and possible mechanisms are discussed. Case presentation A 31-year-old female presented with anaemia and was diagnosed with PRCA in our centre. She also had hypoparathyroidism for 24 years, premature ovarian failure for 10 years, osteoporosis for 5 years, recurrent pneumonia with bronchiectasis for 4 years and chronic diarrhoea for 1 year. Boosted whole-exome analysis showed AIRE heterozygous mutations, confirming the diagnosis as APS1. LGLL was diagnosed during follow-up. The PRCA responded well to glucocorticoid. treatment Conclusion AIRE is causally related to the development of LGLL and consequent PRCA, which may be due to some immunological mechanisms.


2014 ◽  
Vol 172 (1-2) ◽  
pp. 241-247 ◽  
Author(s):  
Paul J.J. Mandigers ◽  
Mirjam B.H.M. Duijvestijn ◽  
Nynke Ankringa ◽  
Sofie Maes ◽  
Elise van Essen ◽  
...  

1993 ◽  
Vol 4 (5) ◽  
pp. 300-302 ◽  
Author(s):  
M Giangaspero ◽  
G Vacirca ◽  
D Morgan ◽  
K S Baboo ◽  
N P Luo ◽  
...  

Bovine viral diarrhoea (BVD) virus is a cosmopolitan pestivirus of animals which is associated with diarrhoea, immunosuppression and synergy with other pathogens. This study was conducted to establish the prevalence of anti-BVD virus antibodies in healthy Zambian adults and those with asymptomatic and symptomatic HIV disease. Sera from 1159 adults were tested for anti-BVD virus antibodies using the indirect immunofluorescence test and the confirmatory Western blot. Of the 1159 sera examined, 180 (15.5%) showed significantly elevated titres of anti-BVD antibodies. These included 70 out of 477 (14.7%) HIV-negative healthy adults; 73 out of 480 (15.2%) of HIV-positive asymptomatic individuals; 23 out of 129 (17.8%) HIV-seropositive patients with associated illnesses excluding diarrhoea; and 14 out of 73 (19.2%) of HIV-seropositive patients with chronic diarrhoea. HIV-seropositive patients with chronic diarrhoea or associated illnesses appear to have significantly increased seroprevalence of anti-BVD virus antibodies ( P = >0.01). The mechanism of interaction between BVD virus and HIV infections and the synergistic effects with other opportunistic pathogens in humans requires definition.


2012 ◽  
Vol 17 (2) ◽  
pp. 20-23
Author(s):  
Audrey K Cook ◽  
Sally Purcell

Gut ◽  
2021 ◽  
pp. gutjnl-2021-326421
Author(s):  
Charles Houdeville ◽  
Suzanne Chartier ◽  
Matthieu Delaye ◽  
Bettina Fabiani ◽  
Nicolas Stocker ◽  
...  

Gut ◽  
2018 ◽  
Vol 69 (1) ◽  
pp. 190-191 ◽  
Author(s):  
Ramesh P Arasaradnam ◽  
Julian R F Walters

2019 ◽  
Vol 12 (5) ◽  
pp. e228942 ◽  
Author(s):  
Anne Claire Billet ◽  
Arnaud Salmon Rousseau ◽  
Lionel Piroth ◽  
Capucine Martins

Entamoeba histolytica is a cosmopolitan pathogenic parasite. It is spread via the feco-oral route and, to a lesser extent, via sexual intercourse. We report a case of hepatic and intestinal amoebiasis in a 67-year-old man who had never travelled to an endemic area. Abdominal CT investigations detected two liver abscesses and chronic colitis. Positive amoebic serology and a positive PCR test for E. histolytica in the hepatic liquid and faeces confirmed the diagnosis. Curative metronidazole and tiliquinol-tilbroquinol were administered successfully. The patient had been contaminated through heterosexual intercourse with his healthy French female partner who was a carrier of the parasite. Though unusual, amoebiasis as a result of sexual transmission should be considered in non-endemic areas in people who have never travelled abroad, particularly in the presence of clinical symptoms such as liver abscesses or chronic diarrhoea.


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