A 25-Year-Old Woman from Zambia With a New-Onset Seizure

With the outbreak of COVID-19 (coronavirus disease 2019) as a global pandemic, various of its neurological manifestations have been reported. We report a case of a 54-year-old male with new-onset seizure who tested positive for severe acute respiratory syndrome coronavirus 2 from a nasopharyngeal swab sample. Investigative findings, which included contrast-enhancing right posterior temporal lobe T2-hyperintensity on brain magnetic resonance imaging, right-sided lateralized periodic discharges on the electroencephalogram, and elevated protein level on cerebrospinal fluid analysis, supported the diagnosis of possible encephalitis from COVID-19 infection. The findings in this case are placed in the context of the existing literature.

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Disseminated Nocardia beijingensis Infection in an Immunocompetent Patient

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001904 ◽

2020 ◽

Author(s):

Moni Roy ◽

Annia Martial ◽

Sharjeel Ahmad

Keyword(s):

Literature Review ◽

Immunocompetent Patient ◽

Chest Ct ◽

Primary Site ◽

Immunocompetent Host ◽

Onset Seizure ◽

Pulmonary System ◽

Life Threatening ◽

Immunocompromised Hosts ◽

New Onset

Nocardia is a genus of aerobic, non-motile and non-spore-forming filamentous branching bacteria with fragmentation into bacillary or coccoid forms. Infections caused by Nocardia often occur in immunocompromised hosts and are potentially life-threatening. Nocardia beijingensis has rarely been reported to cause infection in immunocompetent hosts. We present a case of disseminated infection due to Nocardia beijingensis in a patient with no known medical comorbidities, who presented with new-onset seizure. Another interesting finding in our case is that our patient did not have any pulmonary symptoms despite chest CT showing the pulmonary system as the likely primary site of infection. As per our literature review, this is the seventh reported case of infection due to Nocardia beijingensis in an immunocompetent host.

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New-Onset Seizure Post-Testing Positive for Sars-Cov-2 Virus

International Journal of Clinical Studies and Medical Case Reports ◽

10.46998/ijcmcr.2021.14.000330 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Seyed Mohammad Nahidi

Keyword(s):

Onset Seizure ◽

New Onset

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Neurocysticercosis Diagnosed by Taenia solium PCR on Brain Biopsy

Case Reports in Infectious Diseases ◽

10.1155/2020/8887647 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Sean Wei Xiang Ong ◽

Jean-Marc Chavatte ◽

Jonathan Wei Zhong Chia ◽

Ramez Wadie Kirollos ◽

Yih Yian Sitoh ◽

...

Keyword(s):

Taenia Solium ◽

Granulomatous Inflammation ◽

Brain Biopsy ◽

Onset Seizure ◽

Diagnostic Role ◽

Pcr Products ◽

Polymerase Chain ◽

Temporal Lobe Lesion ◽

New Onset

Neurocysticercosis is a common cause for brain lesions and adult-onset epilepsy in endemic countries. However, diagnosis is challenging in the absence of typical radiologic or histopathologic features. In this case report, we present a case of a 35-year-old male with a new-onset seizure and a rim-enhancing temporal lobe lesion. Radiologic features were nonspecific, and brain biopsy was performed. Histologic features showed only nonspecific granulomatous inflammation, and the diagnosis of neurocysticercosis was confirmed only with polymerase chain reaction (PCR) testing on brain biopsy tissue demonstrating PCR products consistent with Taenia solium. This case highlights the diagnostic role of PCR in such clinical situations whereby the diagnosis is unclear after initial routine evaluation.

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Childhood Neurocysticercosis: Clinico-Radiological Profile and Outcome

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v28i1.1400 ◽

1970 ◽

Vol 28 (1) ◽

pp. 14-16 ◽

Cited By ~ 1

Author(s):

BM Shrestha

Keyword(s):

Secondary Level ◽

Preschool Age ◽

Onset Seizure ◽

Insufficient Information ◽

Mri Findings ◽

Neurological Illness ◽

Preschool Age Children ◽

Neuro Imaging ◽

New Onset

Neurocysticercosis (NCC) is a major cause of neurological illness worldwide. It is the most common identifiable cause of partial seizure especially in the children of developing world. There is insufficient information about NCC in children in Nepal. This study was, therefore, conducted to evaluate the clinical, neuro-radiographic and therapeutic aspects of NCC in children. Material and Methods: 68 children with this neurocysticercosis were studied prospectively in 20 months in the Lumbini Zonal Hospital (LZH), a secondary-level-referral hospital in the Western Nepal. The diagnosis of NCC was based primarily on the neuro-imaging (CT/MRI) findings. Results: The patients were predominantly females (nearly 65%) with age ranging from 2 to 14 years. Preschool-age children constituted 10% of the patients. The three common manifestations were seizures (91%), headache and or vomiting (38%) and hemi and or monoparesis (15%). CT/MRI demonstrated a single parenchymal ring or nodular enhancing lesion (REL) in 84% of cases with perilesional oedema in nearly 90% of cases. A large majority of patients were treated only with the anticonvulsant drugs (ACDs) for 9 months. Follow-up with repeat CT after 6 months showed a complete resolution of NCC in most of the cases without the need for cysticidal treatment. Conclusion: NCC should be considered first in the differential diagnosis of new-onset seizure among the children of developing countries, where taeniasis is endemic. Most of the patients with NC do not need anticysticercal therapy. Keywords: Seizure, Children, Cysticercosis, CNS, Western Nepal. DOI = 10.3126/jnps.v28i1.1400 J. Nepal Paediatr. Soc. Vol.28(1) p.14-16

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