Blood: erythropoiesis — role of folate and vitamin B12

1989 ◽  
pp. 285-296
Author(s):  
J. Hywel Thomas ◽  
Brian Gillham
Keyword(s):  
Vitamin B12 ◽  
Folate And Vitamin B12

scholarly journals FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.

2018 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
Bhongir Aparna Varma ◽  
Srilatha Bashetti ◽  
Rajagopalan Vijayaraghavan ◽  
Kumar Sai Sailesh
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Vitamin B12 ◽  
The Body ◽  
Aberrant Methylation ◽  
Restricted Diet ◽  
Current Review ◽  
Folate And Vitamin B12 ◽  
Methylation Patterns

 Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.

scholarly journals Cytogenetic Observations in Vitamin B12 and Folate Deficiency

Blood ◽  
1966 ◽  
Vol 27 (6) ◽  
pp. 800-815 ◽  
Author(s):  
CLARK W. HEATH ◽  
Lila Fliegelman
Keyword(s):  
Cell Division ◽  
Chromosome Number ◽  
Vitamin B12 ◽  
Chromosome Structure ◽  
Chromosome Breakage ◽  
Medical Complications ◽  
Dna Metabolism ◽  
Cytogenetic Changes ◽  
Folate And Vitamin B12

Abstract Direct marrow cytogenetic preparations were examined in 14 cases of anemia associated with deficiency in vitamin B12 and/or folate. Seven cases showed distinct alterations in chromosome structure consisting of increased chromosome breakage, incomplete chromosome contraction and centromere spreading. These abnormalities were not present after vitamin replacement and were generally less distinct in cases with major medical complications or with only mild megaloblastic changes. No distinct aberrations in chromosome number or karyotype were found. The cytogenetic changes observed seem compatible with current concepts of megaloblastic cell division and with the role of folate and vitamin B12 in DNA metabolism.

scholarly journals FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.

2018 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Bhongir Aparna Varma ◽  
Srilatha Bashetti ◽  
Rajagopalan Vijayaraghavan ◽  
Kumar Sai Sailesh
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Vitamin B12 ◽  
The Body ◽  
Aberrant Methylation ◽  
Restricted Diet ◽  
Current Review ◽  
Folate And Vitamin B12 ◽  
Methylation Patterns

 Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.

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