scholarly journals A novel microfluidic resistive pulse sensor with multiple voltage input channels and a side sensing gate for particle and cell detection

2019 ◽  
Vol 1052 ◽  
pp. 113-123 ◽  
Author(s):  
Tong Zhou ◽  
Yongxin Song ◽  
Yapeng Yuan ◽  
Dongqing Li
2014 ◽  
Vol 36 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Yongxin Song ◽  
Mengqi Li ◽  
Xinxiang Pan ◽  
Qi Wang ◽  
Dongqing Li

Small ◽  
2018 ◽  
Vol 14 (15) ◽  
pp. 1800013 ◽  
Author(s):  
Ran Peng ◽  
Xiaowu Shirley Tang ◽  
Dongqing Li

2020 ◽  
Author(s):  
Rhushabh Maugi ◽  
bernadette gamble ◽  
david bunka ◽  
Mark Platt

A universal aptamer-based sensing strategy is proposed using DNA modified nanocarriers and Resistive Pulse Sensing for the rapid and label free detection of small molecules. The surface of a magnetic nanocarrier was first modified with a ssDNA aka linker which is designed to be partially complimentary in sequence to a ssDNA aptamer. The aptamer and linker form a stable dsDNA complex on the nanocarriers surface. Upon the addition of the target molecule, a conformational change takes place where the aptamer preferentially binds to the target over the linker; causing the aptamer to be released into solution. The RPS measures the change in velocity of the nanocarrier as its surface changes from dsDNA to ssDNA, and its velocity is used as a proxy for the concentration of the target. We illustrate the versatility of the assay by demonstrating the detection of the antibiotic Moxifloxacin, and chemotherapeutics Imatinib and Irinotecan.


2010 ◽  
Author(s):  
Hongpeng Zhang ◽  
Yongxin Song ◽  
Xinxiang Pan ◽  
Yuqing Sun ◽  
Dongqing Li ◽  
...  

2020 ◽  
Author(s):  
Mark Platt ◽  
Eugenie Hunsicker ◽  
Marcus Pollard

Technologies that can detect and characterise particulates in liquids have applications in health, food and environmental monitoring. Here we present a low-cost and high-throughput multiuse counter that classifies a particle’s size, concentration, porosity and shape. Using an additive manufacturing process, we have assembled a reusable flow resistive pulse sensor. The device remains stable for several days with repeat measurements. We demonstrate its use for characterising algae with spherical and rod structures as well as microplastics shed from teabags. We present a methodology that results in a specific signal for microplastics, namely a conductive pulse, in contrast to particles with smooth surfaces such as calibration particles or algae, allowing the presence of microplastics to be easily confirmed and quantified. In addition, the shape of the signal and particle are correlated, giving an extra physical property to characterise suspended particulates. The technology can rapidly screen volumes of liquid, 1 mL/ min, for the presence of microplastics and algae.<br>


Author(s):  
Ashish Jagtiani ◽  
Jiang Zhe ◽  
Bi-min Zhang Newby

We describe an all-electronic, label-free, resistive pulse sensor that utilizes multiple micropores for simultaneous detection and counting of multiple biological particles. Four particle samples were utilized for the sensor testing: 20μm and 40μm polymethacrylate (PM) particles, Juniper pollen and Eastern Cottonwood pollen. Experiments demonstrated that this sensor was able to differentiate and count multiple particle solutions simultaneously through its four micropores fabricated on polymer membranes. Thus the sensing throughput has been improved significantly. Furthermore, the experimental results also proved the feasibility of differentiating various pollens from PM microparticles with the multi-pore resistive pulse sensor, with no need for labeling of samples.


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