The basic anatomical and physiological conditions needed for preparation of a good functioning urinary reservoir are analyzed according to current literature and personal experience. Owing to the need for a schematic and concise exposition, the text has been subdivided under five headings: (I) Metabolic considerations: a) the segment used; b) the duration of contact between intestinal mucosa and urine; c) the size of the exposed intestinal surface. (II) Renal function. (Ill) Physical properties of the reservoir: a) contractility; b) configuration; c) accommodation; d) viscoelasticity. (IV) Carcinogenesis: a) statistical considerations; b) ethiopathogenesis. (V) Clinical consequences of the removal of a normally functioning intestinal segment.