Response to Treatment With Oral Alitretinoin in Patients With Chronic Hand Eczema That Is Refractory to Treatment With Potent Topical Corticosteroids: Experience in 15 Patients

2011 ◽  
Vol 102 (8) ◽  
pp. 616-622
Author(s):  
I.R. Aguayo-Leiva ◽  
S. Urrutia ◽  
P. Jaén-Olasolo
Keyword(s):  
Hand Eczema ◽  
Response To Treatment ◽  
Topical Corticosteroids ◽  
Chronic Hand Eczema

Efficacy of alitretinoin depending on the concomitant use of topical corticosteroids in chronic hand eczema patients

2019 ◽  
Vol 46 (11) ◽  
pp. 998-1005
Author(s):  
Dong Uk Cheon ◽  
Jeong Eun Kim ◽  
Joo Yeon Ko ◽  
Young Suck Ro
Keyword(s):  
Hand Eczema ◽  
Topical Corticosteroids ◽  
Chronic Hand Eczema

Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry

2018 ◽  
Vol 80 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Christian J. Apfelbacher ◽  
Robert F. Ofenloch ◽  
Elke Weisshaar ◽  
Sonja Molin ◽  
Andrea Bauer ◽  
...  
Keyword(s):  
Hand Eczema ◽  
Chronic Hand Eczema

scholarly journals Skin Microbiome in Patients with Hand Eczema and Healthy Controls: A Three-week Prospective Study

2021 ◽  
Author(s):  
Line Brok Nørreslet ◽  
Berit Lilje ◽  
Anna Cäcilia Ingham ◽  
Sofie Marie Edslev ◽  
Maja-Lisa Clausen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Disease Severity ◽  
Amplicon Sequencing ◽  
Hand Eczema ◽  
Skin Microbiome ◽  
Healthy Controls ◽  
16S Rrna Amplicon Sequencing ◽  
Chronic Hand Eczema ◽  
Α Diversity ◽  
Underlying Mechanisms

The pathogenesis of chronic hand eczema remains unclear. Insights into the skin microbiome in hand eczema and its potential relevance to disease severity may help to elucidate the underlying mechanisms of hand eczema. The aim of this study was to characterize the microbiome in patients with hand eczema and healthy controls. A 5-visit prospective study was conducted over a period of 3 weeks. At each visit, bacterial swabs were taken from the hands of patients with hand eczema and controls. The microbiome was examined using DNA extraction and 16S rRNA amplicon sequencing (V3–V4 regions). Fifty patients with hand eczema and 50 controls were included (follow-up rate=100%). The baseline bacterial α-diversity was reduced on the hands of patients with hand eczema compared with controls (effect size=–0.31; 95% confidence interval (95% CI) –0.50; –0.11; p = 0.003). The dysbiosis on the patients’ hands was stable over the study period, was associated with disease severity, and was characterized by reduced bacterial diversity and different bacterial community compositions.

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