Efficacy and safety of oral alitretinoin in chronic hand eczema and palmoplantar pustulosis

This randomized controlled clinical trial was conducted to assess the efficacy and safety of intralesional triamcinolone acetonide in the treatment of chronic hand eczema comparing with topical clobetasol propionate. A total 60 patients of chronic hand eczema were recruited in the study. Thirty patients (Group A) were treated with intralesional triamcinolone acetonide and the rest 30 (Group B) with topical clobetasol propionate. Severity and improvement were assessed using Hand Eczema Severity Index (HECSI) score. The patients of both groups were followed up at 4th week and 12th week. In Group A, median HECSI score at baseline, 4th week and 12th week were 3, 20 and 20 respectively; whereas these scores were 54, 10 and 8 in Group B. In both groups, HECSI score was decreased gradually but the rate was higher in Group B than Group A (p<0.05). Thinning of skin, an adverse effect, was seen in patients of both the intralesional triamcinolone acetonide (10%) and topical clobetasol propionate (16.7%) groups (p>0.05). The result of this study demonstrates that intralesional triamcinolone acetonide is effective and safe in treating chronic hand eczema but less effective than the topical clobetasol.

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Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial

Yearbook of Dermatology and Dermatologic Surgery ◽

10.1016/s0093-3619(08)79135-4 ◽

2009 ◽

Vol 2009 ◽

pp. 87-88

Author(s):

B.H. Thiers

Keyword(s):

Retinoic Acid ◽

Multicentre Trial ◽

Hand Eczema ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Topical Corticosteroids ◽

Chronic Hand Eczema

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To Determine the Efficacy and Safety of Narrow Band UVB (NB-UVB) in Chronic Hand Eczema (CHE)

10.53350/pjmhs211561195 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1195-1197

Author(s):

S. Ali ◽

S. Mohsin ◽

Zeb . ◽

B. Ashraf ◽

M. Nadeem

Keyword(s):

Side Effects ◽

Effective Treatment ◽

Global Assessment ◽

Narrow Band ◽

Hand Eczema ◽

Efficacy And Safety ◽

Effective Treatment Option ◽

Safety And Efficacy ◽

Chronic Hand Eczema ◽

Chronic Eczema

Aim: To d etermin e the safety and efficacy of narrow band ultravoilet B radiations in chronic hand eczema. Methods: 62 patients were enrolled from OPD of Dermatology Unit II, KEMU/ Mayo Hospital, Lahore. They weregiven phototherapy treatment through NB UVB local chamber, t hrice weekly (on fixed days) for a total of 12 weeks or until clearance. Patients were followed up fortnightly for further 1 month and final assessment was done at the end of one month. Physician’s Global Assessment (PGA) Score was used to assess the sever ity of eczema affecting the hands. Results The data was collected from 62 patients with 0% dropout. There was only one patient who had improvement <25%, 4(6.45%) had improvement 25 50%, 8(12.90%) had 51 75% improvement and 49(79.03%)cases had improvem ent >75%. Minimal side effects were seen which included erythema, photosensitivity, itching and pain. Conclusion : NB UBV is a safe as well as effective treatment option for chronic eczema of hands. Keywords : Chronic Hand Eczema, Narrow Band UVB, Physician’s Global Assessment Score.

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