Assessment of Corneal Thickness and Keratocyte Density in a Rabbit Model of Laser In Situ Keratomileusis Using Scanning Laser Confocal Microscopy

Scanning laser confocal microscopy was utilized to visualize sites of hydrogen peroxide release from stimulated neutrophils and lysosomal acid phosphatase in these and other cells using cerium in the detection systems. Imaging of the cerium-containing reactions was achieved by employing the reflectance mode of this instrument. Localization of these products at the light microscope level was direct and did not require other reactions to generate a visible product. This new approach to cerium cytochemistry should prove useful for many applications.

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Correlation of intraocular pressure and central corneal thickness in normal myopic eyes and after laser in situ keratomileusis

Journal of Cataract & Refractive Surgery ◽

10.1016/s0886-3350(98)80222-8 ◽

1998 ◽

Vol 24 (10) ◽

pp. 1320-1325 ◽

Cited By ~ 88

Author(s):

Barry Emara ◽

Louis E. Probst ◽

David P. Tingey ◽

Dennis W. Kennedy ◽

Lisa J. Willms ◽

...

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Laser In Situ Keratomileusis

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Predictors affecting myopic regression in − 6.0D to − 10.0D myopia after laser-assisted subepithelial keratomileusis and laser in situ keratomileusis flap creation with femtosecond laser-assisted or mechanical microkeratome-assisted

International Ophthalmology ◽

10.1007/s10792-019-01179-5 ◽

2019 ◽

Vol 40 (1) ◽

pp. 213-225 ◽

Cited By ~ 1

Author(s):

Jihong Zhou ◽

Wei Gu ◽

Shaowei Li ◽

Lijuan Wu ◽

Yan Gao ◽

...

Keyword(s):

Femtosecond Laser ◽

Contact Lens ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Case Series ◽

Older Age ◽

Laser In Situ Keratomileusis ◽

Corneal Curvature ◽

Case Series Study

Abstract Purpose To investigate the predictive factors of postoperative myopic regression among subjects who have undergone laser-assisted subepithelial keratomileusis (LASEK), laser-assisted in situ keratomileusis (LASIK) flap created with a mechanical microkeratome (MM), and LASIK flap created with a femtosecond laser (FS). All recruited patients had a manifest spherical equivalence (SE) from − 6.0D to − 10.0D myopia. Methods This retrospective, observational case series study analyzed outcomes of refraction at 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. Predictors affecting myopic regression and other covariates were estimated with the Cox proportional hazards model for the three types of surgeries. Results The study enrolled 496 eyes in the LASEK group, 1054 eyes in the FS-LASIK group, and 910 eyes in the MM-LASIK group. At 12 months, from − 6.0D to − 10.0D myopia showed that the survival rates (no myopic regression) were 52.19%, 59.12%, and 58.79% in the MM-LASIK, FS-LASIK, and LASEK groups, respectively. Risk factors for myopic regression included thicker postoperative central corneal thickness (P ≦ 0.01), older age (P ≦ 0.01), aspherical ablation (P = 0.02), and larger transitional zone (TZ) (P = 0.03). Steeper corneal curvature (Kmax) (P = 0.01), thicker preoperative central corneal thickness (P < 0.01), smaller preoperative myopia (P < 0.01), longer duration of myopia (P = 0.02), with contact lens (P < 0.01), and larger optical zone (OZ) (P = 0.02) were protective factors. Among the three groups, the MM-LASIK had the highest risk of postoperative myopic regression (P < 0.01). Conclusions The MM-LASIK group experienced the highest myopic regression, followed by the FS-LASIK and LASEK groups. Older age, aspheric ablation used, thicker postoperative central corneal thickness, and enlarging TZ contribute to myopic regression; steeper preoperative corneal curvature (Kmax), longer duration of myopia, with contact lens, thicker preoperative central corneal thickness, lower manifest refraction SE, and enlarging OZ prevent postoperative myopic regression in myopia from − 6.0D to − 10.0D.

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Comparison of Intraocular Pressure before and after Laser In Situ Keratomileusis Refractive Surgery Measured with Perkins Tonometry, Noncontact Tonometry, and Transpalpebral Tonometry

Journal of Ophthalmology ◽

10.1155/2015/683895 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Isabel Cacho ◽

Juan Sanchez-Naves ◽

Laura Batres ◽

Jesús Pintor ◽

Gonzalo Carracedo

Keyword(s):

Intraocular Pressure ◽

Refractive Surgery ◽

Corneal Thickness ◽

Laser In Situ Keratomileusis ◽

Spherical Equivalent ◽

Transpalpebral Tonometry ◽

Spherical Equivalent Refraction ◽

Before And After ◽

Noncontact Tonometry

Purpose. To compare the intraocular pressure (IOP) before and after Laser In Situ Keratomileusis (LASIK), measured by Diaton, Perkins, and noncontact air pulse tonometers.Methods. Fifty-seven patients with a mean age of 34.88 were scheduled for myopia LASIK treatment. Spherical equivalent refraction (SER), corneal curvature (K), and central corneal thickness (CCT) and superior corneal thickness (SCT) were obtained before and after LASIK surgery. IOP values before and after surgery were measured using Diaton, Perkins, and noncontact air pulse tonometers.Results. The IOP values before and after LASIK surgery using Perkins tonometer and air tonometers were statistically significant (p<0.05). However, no significant differences were found (p>0.05) for IOP values measured with Diaton tonometer. CCT decreases significantly after surgery (p<0.05) but no statistical differences were found in SCT (p=0.08). Correlations between pre- and postsurgery were found for all tonometers used, withp=0.001andr=0.434for the air pulse tonometer,p=0.008andr=0.355for Perkins, andp<0.001andr=0.637for Diaton.Conclusion. Transpalpebral tonometry may be useful for measuring postsurgery IOP after myopic LASIK ablation because this technique is not influenced by the treatment.

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Twelve-Year Follow-Up of Laser In Situ Keratomileusis for Moderate to High Myopia

BioMed Research International ◽

10.1155/2017/9391436 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Tetsuya Ikeda ◽

Kimiya Shimizu ◽

Akihito Igarashi ◽

Sumie Kasahara ◽

Kazutaka Kamiya

Keyword(s):

High Myopia ◽

Central Corneal Thickness ◽

Pearson Correlation ◽

Corneal Thickness ◽

Laser In Situ Keratomileusis ◽

Manifest Refraction ◽

Observation Period

Purpose. To assess the long-term clinical outcomes of conventional laser in situ keratomileusis (LASIK) for moderate to high myopia.Methods. We retrospectively examined sixty-eight eyes of 37 consecutive patients who underwent conventional LASIK for the correction of myopia (−3.00 to −12.75 diopters (D)). At 3 months and 1, 4, 8, and 12 years postoperatively, we assessed the safety, efficacy, predictability, stability, mean keratometry, central corneal thickness, and adverse events.Results. The safety and efficacy indices were0.82±0.29and0.67±0.37, respectively, 12 years postoperatively. At 12 years, 53% and 75% of the eyes were within 0.5 and 1.0 D, respectively, of the targeted correction. Manifest refraction changes of −0.74±0.99 D occurred from 3 months to 12 years after LASIK (p<0.001). We found a significant correlation of refractive regression with the changes in keratometric readings from 3 months to 12 years postoperatively (Pearson correlation coefficient,r=-0.28,p=0.02), but not with the changes in central corneal thickness (r=-0.08,p=0.63). No vision-threatening complications occurred in any case.Conclusions. Conventional LASIK offered good safety outcomes during the 12-year observation period. However, the efficacy and the predictability gradually decreased with time owing to myopic regression in relation to corneal steepening.

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