Relationship between 1,5 anhydroglucitol, glycemia, and breastfeeding during pregnancy and postpartum

Background: In clinical pharmacokinetic (PK) studies, pregnant women are significantly underrepresented because of ethical and legal reasons which lead to a paucity of information on potential PK changes in this population. As a consequence, pharmacometric tools became instrumental to explore and quantify the impact of PK changes during pregnancy. Methods: We explore and discuss the typical characteristics of population PK and physiologically based pharmacokinetic (PBPK) models with a specific focus on pregnancy and postpartum. Results: Population PK models enable the analysis of dense, sparse or unbalanced data to explore covariates in order to (partly) explain inter-individual variability (including pregnancy) and to individualize dosing. For population PK models, we subsequently used an illustrative approach with ketorolac data to highlight the relevance of enantiomer specific modeling for racemic drugs during pregnancy, while data on antibiotic prophylaxis (cefazolin) during surgery illustrate the specific characteristics of the fetal compartments in the presence of timeconcentration profiles. For PBPK models, an overview on the current status of reports and papers during pregnancy is followed by a PBPK cefuroxime model to illustrate the added benefit of PBPK in evaluating dosing regimens in pregnant women. Conclusions: Pharmacometric tools became very instrumental to improve perinatal pharmacology. However, to reach their full potential, multidisciplinary collaboration and structured efforts are needed to generate more information from already available datasets, to share data and models, and to stimulate cross talk between clinicians and pharmacometricians to generate specific observations (pathophysiology during pregnancy, breastfeeding) needed to further develop the field.

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Editorial: Active Pregnancy - Benefits and Recommendations of Physical Activity and a Healthy Lifestyle Throughout Pregnancy and Postpartum

Current Women s Health Reviews ◽

10.2174/157340481101150914200642 ◽

2015 ◽

Vol 11 (1) ◽

pp. 2-2

Author(s):

Rita Santos-Rocha

Keyword(s):

Physical Activity ◽

Healthy Lifestyle ◽

Pregnancy And Postpartum

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Design of the Tool (web) EMAeHealth supporting decision-making during pregnancy and postpartum: Collaborative Action Research Study. (Preprint)

10.2196/preprints.25421 ◽

2020 ◽

Author(s):

Isabel Artieta-Pinedo ◽

Carmen Paz-Pascual ◽

Paola Bully ◽

Maite Espinosa ◽

Keyword(s):

Action Research ◽

Maternal Education ◽

Monitoring And Evaluation ◽

Research Process ◽

Collaborative Action Research ◽

Public Healthcare ◽

Self Assessment ◽

Collaborative Action ◽

Patient Decision ◽

Pregnancy And Postpartum

BACKGROUND Background: Despite the benefit it can give women, Maternal Education needs new tools that increase its effectiveness and scope OBJECTIVE To develop a multifunctional, personalized eHealth platform aimed at the self-management of health in relation to maternity METHODS The International Patient Decision Aid Standards (IPDAS) were applied. A website prototype was developed for implementation in the public health system using a collaborative action research process in which experts and patients participate, with qualitative research techniques as well as prioritization and consensus techniques. RESULTS A website is proposed which includes (1) systematically updated information related to clinical practice guidelines, (2) interaction between peers and users/professionals, (3) instruments for self-assessment of health needs as a basis for working on counseling, agreement on actions, help in the search for resources, monitoring and evaluation of results and (4) access for women to their clinical data and the option of sharing them with other health agents. These components, with different access requirements, would be permanently reviewed through iterative cycles depending on the frequency and effectiveness resulting from their use and would be accessible from any digital device CONCLUSIONS This public healthcare website would facilitate use, maintenance and effectiveness to increase quality of care without increasing costs. The participation of professionals and users in the creation of new tools will result in greater satisfaction with their use, with the decisions made, and with the decision process itself.

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Serial Levels of Serum Organochlorines During Pregnancy and Postpartum

Archives of Environmental Health An International Journal ◽

10.1080/00039899909602244 ◽

1999 ◽

Vol 54 (2) ◽

pp. 110-114 ◽

Cited By ~ 93

Author(s):

Matthew P. Longnecker ◽

Mark A. Klebanoff ◽

Beth C. Gladen ◽

Heinz W. Berendes

Keyword(s):

Pregnancy And Postpartum

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