scholarly journals Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis

2021 ◽  
Author(s):  
Hiroshi Kumanomidou ◽  
Kengo Kanai ◽  
Aiko Oka ◽  
Takenori Haruna ◽  
Yuji Hirata ◽  
...  
Keyword(s):  
Japanese Cedar ◽  
Ocular Symptom ◽  
Utility Values ◽  
Symptom Scores ◽  
Japanese Cedar Pollinosis

scholarly journals Distribution of Different Species of the Bacteroides fragilis Group in Individuals with Japanese Cedar Pollinosis

2008 ◽  
Vol 74 (21) ◽  
pp. 6814-6817 ◽  
Author(s):  
Toshitaka Odamaki ◽  
Jin-Zhong Xiao ◽  
Mitsuo Sakamoto ◽  
Shizuki Kondo ◽  
Tomoko Yaeshima ◽  
...  
Keyword(s):  
Pollen Season ◽  
Immunoglobulin E ◽  
Bacteroides Fragilis ◽  
Japanese Cedar ◽  
Cell Numbers ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Symptom Scores ◽  
Bacteroides Fragilis Group ◽  
Japanese Cedar Pollinosis

ABSTRACT We investigated associations of species of the Bacteroides fragilis group with Japanese cedar pollinosis (JCPsis). Cell numbers of Bacteroides fragilis and Bacteroides intestinalis were significantly higher in JCPsis subjects than in non-JCPsis subjects before the pollen season. They correlated positively with both symptom scores and JCPsis-specific immunoglobulin E levels.

Formation of IgE-Allergen-CD23 Complex Changes in Children Treated with Subcutaneous Immunotherapy for Japanese Cedar Pollinosis

2020 ◽  
pp. 1-5
Author(s):  
Tomoyuki Asaumi ◽  
Sakura Sato ◽  
Noriyuki Yanagida ◽  
Hiroki Matsuhara ◽  
Satoko Kobayashi ◽  
...  
Keyword(s):  
Binding Assay ◽  
Japanese Cedar ◽  
Specific Ige ◽  
Subcutaneous Immunotherapy ◽  
Ocular Symptoms ◽  
Symptom Scores ◽  
A Cell ◽  
Specific Igg ◽  
Japanese Cedar Pollinosis ◽  
Blocking Antibodies

<b><i>Background:</i></b> Subcutaneous immunotherapy (SCIT) is used to treat Japanese cedar (JC) pollinosis. The formation of IgE-allergen-CD23 complex after SCIT for JC pollinosis has not yet been fully elucidated. <b><i>Objective:</i></b> The objective of this study was to investigate the formation of IgE-allergen-CD23 complex after SCIT for JC pollinosis. <b><i>Methods:</i></b> Eleven patients were treated with 3-year SCIT for JC pollinosis at Sa­gamihara National Hospital from 2013 to 2014. Nasal and ocular symptoms (in terms of symptom scores) during the scattering of JC pollen and immunological changes were investigated. Levels of JC pollen-specific antibodies (IgE and IgG<sub>4</sub>) were measured by ImmunoCAP assays. To detect the changes in allergen-presenting ability of B cells, the levels of IgE-allergen-CD23 complexes in serum were measured by a cell-free, enzyme-linked immunosorbent-facilitated antigen-binding assay. <b><i>Results:</i></b> The median (interquartile range) age of the subjects was 8 (6–10) years. Three patients (27%) had comorbid atopic dermatitis, and 5 patients (45%) had comorbid bronchial asthma. Before starting SCIT, the total IgE level was 373 (75–2,870) kU/L, and the level of JC pollen-specific IgE was 77.2 (15.4–528) kU<sub>A</sub>/L. Symptom scores improved significantly from the year after treatment. JC pollen-specific IgE levels did not change after 3 years of treatment. JC pollen-specific IgG<sub>4</sub> levels increased significantly throughout the treatment period. The levels of IgE-allergen-CD23 complexes decreased significantly after 3 years of treatment. <b><i>Conclusion:</i></b> The ability of IgE-allergen complexes to bind to CD23 decreased after SCIT, suggesting that increasing levels of IgE-blocking antibodies, including IgG<sub>4</sub>, may play an important role in the mechanism of SCIT.

Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a

Cytokine ◽  
2015 ◽  
Vol 75 (1) ◽  
pp. 181-185 ◽  
Author(s):  
Masafumi Sakashita ◽  
Takechiyo Yamada ◽  
Yoshimasa Imoto ◽  
Tomomitsu Hirota ◽  
Mayumi Tamari ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Japanese Cedar ◽  
Complement Components ◽  
Japanese Cedar Pollinosis

scholarly journals Effect of Fluticasone Furoate in Patients with Japanese Cedar Pollinosis

2013 ◽  
Vol 137 (0) ◽  
pp. 42-43
Author(s):  
Takahiro Ichihara ◽  
Tetsuya Terada ◽  
Kanako Fujii ◽  
Ayumi Yuki ◽  
Ryo Kawata
Keyword(s):  
Japanese Cedar ◽  
Fluticasone Furoate ◽  
Japanese Cedar Pollinosis
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