Inpatient Proton Pump Inhibitor Administration and Hospital-Acquired Clostridium difficile Infection: Evidence and Possible Mechanism

2018 ◽  
Vol 131 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Eric Wombwell ◽  
Megan E. Chittum ◽  
Kayla R. Leeser
Keyword(s):  
Clostridium Difficile ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Clostridium Difficile Infection ◽  
Hospital Acquired

Trends in Oral Antibiotic, Proton Pump Inhibitor, and Histamine 2 Receptor Blocker Prescription Patterns for Children Compared With Adults

2015 ◽  
Vol 55 (8) ◽  
pp. 712-716 ◽  
Author(s):  
Howard S. Faden ◽  
Chan-Xing Ma
Keyword(s):  
Clostridium Difficile ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Clostridium Difficile Infection ◽  
Antibiotic Prescription ◽  
Receptor Blocker ◽  
Oral Antibiotic ◽  
Oral Antibiotics ◽  
Prescription Patterns ◽  
Prescription Rates

The use of antibiotics, proton pump inhibitor (PPI), and histamine 2 receptor blocker (H2B) was compared between children and adults in the community from 2005 through 2011. Antibiotic prescription rates remained stable for children, but increased significantly for adults, P = .03. PPI prescription rates increased for children, P = .02 and for adults, P = .009. H2B prescription rates increased for children, P = .03, but not for adults. Antibiotic prescription rates were significantly higher in children than adults in all 7 years, P < .0001. In contrast, PPI prescription rates were significantly higher in adults than children in all 7 years, P < .0001. H2B prescription rates were significantly higher in adults than children 1 to 18 years old P < .0001; however, H2B prescription rates were highest in children <1 year old, P = .0001. The high use of oral antibiotics, PPI, and H2B among outpatients may be a contributing factor to the rise of Clostridium difficile infection in the community.

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