scholarly journals In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

2011 ◽  
Vol 92 (2) ◽  
pp. 329-340 ◽  
Author(s):  
Yohichi Kumaki ◽  
Craig W. Day ◽  
Donald F. Smee ◽  
John D. Morrey ◽  
Dale L. Barnard
Keyword(s):  
Highly Pathogenic Avian Influenza ◽  
H1n1 Virus ◽  
Pandemic H1n1 ◽  
Virus Infections ◽  
Highly Pathogenic ◽  
In Vivo Efficacy ◽  
Pathogenic Avian Influenza ◽  
Influenza H5n1

scholarly journals Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses

2015 ◽  
Vol 90 (1) ◽  
pp. 616-623 ◽  
Author(s):  
Min-Suk Song ◽  
Yun Hee Baek ◽  
Philippe Noriel Q. Pascua ◽  
Hyeok-il Kwon ◽  
Eun-Ha Kim ◽  
...  
Keyword(s):  
Avian Influenza ◽  
H5n1 Virus ◽  
Highly Pathogenic Avian Influenza ◽  
Pandemic H1n1 ◽  
Pathogenic Potential ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Avian Influenza H5n1 ◽  
Influenza H5n1

Coinfection of ferrets with H5N1 and pH1N1 viruses resulted in two predominate genotypes in the lungs containing surface genes of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic H1N1 2009 (pH1N1). Compared to parental strains, these reassortants exhibited increased growth and virulence in vitro and in mice but failed to be transmitted indirectly to naive contact ferrets. Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants.

In Vitro and In Vivo Efficacy of Combinational Therapy with Favipiravir (T-705) and Oseltamivir Against Influenza A/CA/04/09 Pandemic H1N1 Virus

2010 ◽  
Vol 86 (1) ◽  
pp. A26
Author(s):  
Dale Barnard ◽  
Yousuke Furuta ◽  
Klaus Klummp ◽  
Donald Smee ◽  
John Morrey ◽  
...  
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
Pandemic H1n1 ◽  
In Vivo Efficacy ◽  
Combinational Therapy
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