The efficient one-pot condensation of aldehyde, dimedone, and phthalhydrazide
has been achieved in the presence of a catalytic amount of phospho sulfonic
acid as a novel environmentally benign heterogeneous solid acid under
solvent-free conditions. A diversified 2H-indazolo[1,2-b]phthalazinetrione
derivatives were prepared in good to excellent yields in short time. The
economical factors (time, cost, waste etc.) for this three-component reaction
hold promise for the future of organic synthesis.
Cellulose sulfuric acid as a bio-supported and recyclable solid acid catalyst for the one-pot synthesis of 2,4,5-triarylimidazoles under microwave irradiation