No clinical or radiographic difference seen in arthroscopic Bankart repair with knotted versus knotless suture anchors. A randomized controlled trial at short term follow up.

2021 ◽  
Author(s):  
Frederico Lafraia Lobo ◽  
Mauro Emilio Conforto Gracitelli ◽  
Eduardo Angeli Malavolta ◽  
Renata Vidal Leão ◽  
Fernando Brandão de Andrade e Silva ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Bankart Repair ◽  
Suture Anchors ◽  
Short Term ◽  
Randomized Controlled ◽  
Arthroscopic Bankart Repair

scholarly journals Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine

2021 ◽  
Author(s):  
Ferdows Atiq ◽  
Jens van de Wouw ◽  
Oana Sorop ◽  
Ilkka Heinonen ◽  
Moniek P. M. de Maat ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Randomized Controlled Trial ◽  
Endothelial Dysfunction ◽  
Controlled Trial ◽  
Short Term ◽  
Randomized Controlled ◽  
Von Willebrand ◽  
Willebrand Factor

AbstractIt is well known that high von Willebrand factor (VWF) and factor VIII (FVIII) levels are associated with an increased risk of cardiovascular disease. It is still debated whether VWF and FVIII are biomarkers of endothelial dysfunction and atherosclerosis or whether they have a direct causative role. Therefore, we aimed to unravel the pathophysiological pathways of increased VWF and FVIII levels associated with cardiovascular risk factors. First, we performed a randomized controlled trial in 34 Göttingen miniswine. Diabetes mellitus (DM) was induced with streptozotocin and hypercholesterolemia (HC) via a high-fat diet in 18 swine (DM + HC), while 16 healthy swine served as controls. After 5 months of follow-up, FVIII activity (FVIII:C) was significantly higher in DM + HC swine (5.85 IU/mL [5.00–6.81]) compared with controls (4.57 [3.76–5.40], p = 0.010), whereas VWF antigen (VWF:Ag) was similar (respectively 0.34 IU/mL [0.28–0.39] vs. 0.34 [0.31–0.38], p = 0.644). DM + HC swine had no endothelial dysfunction or atherosclerosis during this short-term follow-up. Subsequently, we performed a long-term (15 months) longitudinal cohort study in 10 Landrace–Yorkshire swine, in five of which HC and in five combined DM + HC were induced. VWF:Ag was higher at 15 months compared with 9 months in HC (0.37 [0.32–0.42] vs. 0.27 [0.23–0.40], p = 0.042) and DM + HC (0.33 [0.32–0.37] vs. 0.25 [0.24–0.33], p = 0.042). Both long-term groups had endothelial dysfunction compared with controls and atherosclerosis after 15 months. In conclusion, short-term hyperglycemia and dyslipidemia increase FVIII, independent of VWF. Long-term DM and HC increase VWF via endothelial dysfunction and atherosclerosis. Therefore, VWF seems to be a biomarker for advanced cardiovascular disease.

scholarly journals Short-term effects of enhanced treatment for depression in primary care: results from a randomized controlled trial

2005 ◽  
Vol 36 (1) ◽  
pp. 15-26 ◽  
Author(s):  
A. SMIT ◽  
H. KLUITER ◽  
H. J. CONRADI ◽  
K. VAN DER MEER ◽  
B. G. TIEMENS ◽  
...  
Keyword(s):  
Primary Care ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Modalities ◽  
Psychiatric Evaluation ◽  
Patient Acceptance ◽  
Short Term ◽  
Psychiatric Interview ◽  
Randomized Controlled

Background. Depression is a highly prevalent, often recurring or persistent disorder. The majority of patients are initially seen and treated in primary care. Effective treatments are available, but possibilities for providing adequate follow-up care are often limited in this setting. This study assesses the effectiveness of primary-care-based enhanced treatment modalities on short-term patient outcomes.Method. In a randomized controlled trial we evaluated a psycho-educational self-management intervention. We included 267 adult patients meeting criteria for a DSM-IV diagnosis of major depressive disorder, assessed by a structured psychiatric interview. Patients were randomly assigned to: the Depression Recurrence Prevention (DRP) program (n=112); a combination of the DRP program with psychiatric consultation (PC+DRP, n=39); a combination with brief cognitive behavior therapy (CBT+DRP, n=44); and care as usual (CAU, n=72). Follow-up assessments were made at 3 months (response 90%) and 6 months (85%).Results. Patient acceptance of enhanced care was good. The mean duration of the index episode was 11 weeks (S.D.=9·78) and similar in CAU and enhanced care. Recovery rate after 6 months was 67% overall; 17% of all participants remained depressed for the entire 6-month period.Conclusion. Enhanced care did not result in better short-term outcomes. We found no evidence that the DRP program was more effective than CAU and no indications for added beneficial effects of either the psychiatric evaluation or the CBT treatment to the basic format of the DRP program. Observed depression treatment rates in CAU were high.

scholarly journals Does the Addition of Pain Neurophysiology Education to a Therapeutic Exercise Program Improve Physical Function in Women with Fibromyalgia Syndrome? Secondary Analysis of a Randomized Controlled Trial

2021 ◽  
Vol 10 (11) ◽  
pp. 2518
Author(s):  
Luis Ceballos-Laita ◽  
María Teresa Mingo-Gómez ◽  
Elena Estébanez-de-Miguel ◽  
Elena Bueno-Gracia ◽  
Francisto José Navas-Cámara ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Physical Function ◽  
Sleep Disturbances ◽  
Fibromyalgia Syndrome ◽  
Controlled Trial ◽  
Therapeutic Exercise ◽  
Short Term ◽  
Timed Up And Go ◽  
Randomized Controlled

Therapeutic exercise (TE) is one of the most investigated approaches for the management of FMS. Pain neurophysiology education (PNE) helps toward understanding the pain condition, leading to maladaptive pain cognitions and coping strategies in patients with chronic pain. Our study aimed to assess the effects of therapeutic exercise and pain neurophysiology education versus TE in isolation on fatigue, sleep disturbances, and physical function in the short term and at three months of follow-up in women with fibromyalgia syndrome (FMS). A single-blind randomized controlled trial was carried out. A total of 32 women with FMS referred from medical doctors and fibromyalgia association were randomized in 2 groups: PNE + TE group or TE group. Fatigue and sleep disturbances (Visual Analog Score) and physical function (Senior Fitness Test) were assessed before, after intervention, and at three months of follow-up. Significant improvements were achieved in the Timed Up and Go test (p = 0.042) and Arm Curl test (p = 0.043) after intervention and on handgrip in the non-dominant side at three months of follow-up (p = 0.036) on the PNE + TE group. No between-groups differences were found for fatigue, sleep disturbances, and the rest of test included in the Senior Fitness Test. In conclusion, these results suggest that PNE + TE appears to be more effective than TE in isolation for the improvement of physical function (Timed Up and Go test and Arm Curl test) in women with FMS in the short term.

scholarly journals Methylprednisolone Acetate Versus Dexamethasone Injection for Trigger Finger: A Double-blind Randomized Controlled Trial

2021 ◽  
Author(s):  
Porames Suwanno ◽  
Chaiwat Chuaychoosakoon
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Trigger Finger ◽  
Methylprednisolone Acetate ◽  
Analog Scale ◽  
Short Term ◽  
Double Blind ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial

Objective: The study investigated the resolution of triggering by either a soluble methylprednisolone acetate or dexamethasone injection for idiopathic trigger finger at 24-week after injection.Material and Methods: One hundred and six patients were enrolled in a prospective randomized controlled trial (53 methylprednisolone acetate arms, 53 dexamethasone arms). The outcome was evaluated at 2, 6, 12 and 24-week follow-up.Results: The absence of triggering was documented in 32 of 43, 36 of 41 patients in the methylprednisolone cohort and in 20 of 43, 29 of 32 patients in the dexamethasone cohort at 6 and 24-week after injection. The methylprednisolone acetate cohort had significantly better satisfaction on a visual analog scale, tenderness, and locking at 2-week follow-up, and had significantly better satisfaction on resolution of triggering, tenderness, snapping, locking and the Disabilities of the Arm, Shoulder and Hand score at 6-week follow-up compared to those in the dexamethasone cohort.Conclusion: Methylprednisolone acetate is better in short term clinical outcomes than dexamethasone

Usefulness of corset adoption after single-level lumbar discectomy: a randomized controlled trial

2018 ◽  
Vol 28 (5) ◽  
pp. 481-485 ◽  
Author(s):  
Cesare Zoia ◽  
Daniele Bongetta ◽  
Cristiano Alicino ◽  
Marcella Chimenti ◽  
Raffaelino Pugliese ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Lumbar Discectomy ◽  
Foraminal Stenosis ◽  
Short Term ◽  
Single Level ◽  
Randomized Controlled ◽  
Midterm Outcome ◽  
Disability Questionnaire

OBJECTIVEIn this paper, the authors sought to verify whether corset adoption could improve the short-term and midterm outcome scores of patients after single-level lumbar discectomy.METHODSA monocentric, randomized controlled trial of 54 consecutive patients who underwent single-level lumbar discectomy at the authors’ institution was performed from September 2014 to August 2015. Patients were randomly assigned to use or not use a lumbar corset in the upright position. Patients with previous interventions for disc herniation or with concomitant canal or foraminal stenosis were excluded. The visual analog scale, Oswestry Disability Index, and Roland Morris Disability Questionnaire were used to compare groups at the 1- and 6-month follow-up time points.RESULTSNo significant differences between the 2 groups were reported at either time point for any given outcome irrespective of the scale used.CONCLUSIONSCorset adoption does not improve the short-term and midterm outcomes of patients after single-level lumbar discectomy.

scholarly journals Efficacy of dignity therapy for depression and anxiety in terminally ill patients: Early results of a randomized controlled trial

2013 ◽  
Vol 11 (6) ◽  
pp. 481-489 ◽  
Author(s):  
Miguel Julião ◽  
António Barbosa ◽  
Fátima Oliveira ◽  
Baltazar Nunes ◽  
António Vaz Carneiro
Keyword(s):  
Palliative Care ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Terminally Ill ◽  
Depression And Anxiety ◽  
Short Term ◽  
Symptoms Of Depression ◽  
Randomized Controlled ◽  
Dignity Therapy

AbstractObjective:Dignity therapy (DT) is a short-term psychotherapy developed for patients living with a life-limiting illness. Our aim was to determine the influence of DT on symptoms of depression and anxiety in people with a life-threatening disease with high level of distress, referred to an inpatient palliative care unit.Method:This was an open-label randomized controlled trial. Sixty terminally ill patients were randomly assigned to one of two groups: intervention group (DT+ standard palliative care [SPC]) or control group (SPC alone). The main outcomes were symptoms of depression and anxiety, measured with the Hospital Anxiety and Depression Scale, assessed at baseline, day 4, day 15, and day 30 of follow-up.Results:Of the 60 participants, 29 were randomized to DT and 31 to SPC. Baseline characteristics were similar between the two groups. DT was associated with a significant decrease in depressive symptoms at day 4 and day 15 (mean = −4.46, 95% CI, −6.91–2.02, p = 0.001; mean= −3.96, 95% CI, −7.33 to −0.61; p = 0.022, respectively), but not at day 30 (mean = −3.33, 95% CI, −7.32–0.65, p = 0.097). DT was also associated with a significant decrease in anxiety symptoms at each follow-up (mean= −3.96, 95% CI, −6.66 to −1.25, p = 0.005; mean= −6.19, 95% CI, −10.49 to −1.88, p = 0.006; mean = −5.07, 95% CI, −10.22 to −0.09, p = 0.054, respectively).Significance of results:DT appears to have a short-term beneficial effect on the depression and anxiety symptoms that often accompany patients at the end of their lives. Future research with larger samples compared with other treatments is needed to better understand the potential benefits of this psychotherapy.

Sign in / Sign up

Export Citation Format

Share Document