Pulmonary artery aneurysms in Behçet's disease treated with anti-TNFα: A case series and review of the literature

Pulmonary artery aneurysms (PAAs) are the most common type of pulmonary involvement in Behçet's disease. However, the relationships between clinical features and prognosis have not been sufficiently evaluated. This article describes the results of a comprehensive review, revealing that PAAs have a predilection for hemoptysis manifestations, increased dimensions, right lower lobar location, multiplicity and concurrent intramural thrombus formation. Surgical intervention was needed in one third of patients. Patients with massive hemoptysis and PAA rupture warranted emergency operations. Conservatively treated patients were prone to PAA progression; interventional embolization was associated with higher risks of recurrence and reintervention for PAAs; and surgically treated patients exhibited the highest mortality rates. In conclusion, PAAs in Behçet's disease are characterized by a predilection for hemoptysis manifestations, right lower lobar location, multiplicity, and concurrent intramural thrombus formation. Both the condition itself and the surgical operations it warrants are linked with high mortality due to PAA hemorrhage.

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CT findings of pulmonary artery aneurysms during treatment for Behçet's disease.

American Journal of Roentgenology ◽

10.2214/ajr.172.3.10063870 ◽

1999 ◽

Vol 172 (3) ◽

pp. 729-733 ◽

Cited By ~ 83

Author(s):

M Tunaci ◽

B Ozkorkmaz ◽

A Tunaci ◽

A Gül ◽

G Engin ◽

...

Keyword(s):

Pulmonary Artery ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease ◽

Ct Findings ◽

Pulmonary Artery Aneurysms

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A Behcet’s Disease Patient with Right Ventricular Thrombus, Pulmonary Artery Aneurysms, and Deep Vein Thrombosis Complicating Recurrent Pulmonary Thromboembolism

Case Reports in Pulmonology ◽

10.1155/2013/492321 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4

Author(s):

Selvi Aşker ◽

Müntecep Aşker ◽

Özgür Gürsu ◽

Rıdvan Mercan ◽

Özgür Bülent Timuçin

Keyword(s):

Deep Vein Thrombosis ◽

Pulmonary Artery ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Pulmonary Thromboembolism ◽

Behcet's Disease ◽

Vein Thrombosis ◽

Pulmonary Artery Aneurysms ◽

Deep Vein

Intracardiac thrombus, pulmonary artery aneurysms, deep vein thrombosis, and pulmonary thromboembolism are rarely seen symptoms of Behcet’s disease. A 20-year-old female patient was admitted for complaints of cough, fever, palpitations, and chest pain. On the dynamic thorax computed tomograms (CT) obtained because of significantly enlarged hilar structures seen on chest radiograms, aneurysmal dilatation of the pulmonary artery segments bilaterally, chronic thrombus with collapse, and consolidation substances compatible with pulmonary embolism involving both lower lobes have been observed. It is learned that, four years ago, the patient had been diagnosed with Behcet’s disease and received colchicine treatment but not regularly. The patient was hospitalized. On the transthoracic echocardiogram, a thrombosis with a dimension of 4.2 × 1.6 cm was recognized in the right ventricle. On abdomen CT, aneurysmal iliac veins and deep vein thrombus on Doppler ultrasonograms were diagnosed. At the controls after three months of immunosuppressive and anticoagulant therapies, some clinical and radiological improvements were recognized. The patient suspended the treatment for a month and the thrombus recurred. We present our case in order to show the effectiveness of immunosuppressive and anticoagulant therapies and rarely seen pulmonary thromboembolism in recurrent Behcet’s disease.

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