scholarly journals Costs of Hematopoietic Cell Transplantation: Comparison of Umbilical Cord Blood and Matched Related Donor Transplantation and the Impact of Posttransplant Complications

2009 ◽  
Vol 15 (5) ◽  
pp. 564-573 ◽  
Author(s):  
Navneet S. Majhail ◽  
Jaya M. Mothukuri ◽  
Claudio G. Brunstein ◽  
Daniel J. Weisdorf
Blood ◽  
2003 ◽  
Vol 101 (11) ◽  
pp. 4233-4244 ◽  
Author(s):  
Satkiran S. Grewal ◽  
Juliet N. Barker ◽  
Stella M. Davies ◽  
John E. Wagner

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 102
Author(s):  
Hany Elmariah ◽  
Claudio G. Brunstein ◽  
Nelli Bejanyan

Allogeneic hematopoietic cell transplantation (HCT) is the only potentially curative therapy for a variety of hematologic diseases. However, this therapeutic platform is limited by an initial period when patients are profoundly immunocompromised. There is gradual immune recovery over time, that varies by transplant platform. Here, we review immune reconstitution after allogeneic HCT with a specific focus on two alternative donor platforms that have dramatically improved access to allogeneic HCT for patients who lack an HLA-matched related or unrelated donor: haploidentical and umbilical cord blood HCT. Despite challenges, interventions are available to mitigate the risks during the immunocompromised period including antimicrobial prophylaxis, modified immune suppression strategies, graft manipulation, and emerging adoptive cell therapies. Such interventions can improve the potential for long-term overall survival after allogeneic HCT.


2011 ◽  
Vol 93 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Shohei Yamamoto ◽  
Hirokazu Ikeda ◽  
Daisuke Toyama ◽  
Mayumi Hayashi ◽  
Kousuke Akiyama ◽  
...  

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