scholarly journals Early Human Herpesvirus Type 6 Reactivation in Umbilical Cord Blood Allogeneic Stem Cell Transplantation

2014 ◽  
Vol 20 (2) ◽  
pp. S218-S219
Author(s):  
Frank Cirrone ◽  
Cindy Ippoliti ◽  
Koen van Besien
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Allogeneic Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Human Herpesvirus ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type ◽  
Early Human

Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation

2016 ◽  
Vol 57 (11) ◽  
pp. 2555-2559 ◽  
Author(s):  
Frank Cirrone ◽  
Cindy Ippoliti ◽  
Hanhan Wang ◽  
Xi Kathy Zhou ◽  
Usama Gergis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Allogeneic Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Early Human ◽  
Human Herpes Virus Type

scholarly journals Long-Lasting HHV-6 Reactivation in Long-Term Adult Survivors After Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation

2014 ◽  
Vol 210 (4) ◽  
pp. 567-570 ◽  
Author(s):  
Marina Illiaquer ◽  
Florent Malard ◽  
Thierry Guillaume ◽  
Berthe-Marie Imbert-Marcille ◽  
Jacques Delaunay ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Umbilical Cord ◽  
Allogeneic Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Adult Survivors

scholarly journals Umbilical Cord Blood as an Alternate Donor Sources for High Risk Elderly Patients Undergoing Allogeneic Stem Cell Transplantation for Hematological Malignancies

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Patrick Hagen ◽  
◽  
William Adams ◽  
Shruti Singh ◽  
Shuai Qin ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Risk ◽  
Stem Cell Transplantation ◽  
Elderly Patients ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Allogeneic Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Hematological Malignancies ◽  
Donor Source

Allogeneic stem cell transplantation remains the only curative option for many hematological malignancies. Umbilical cord blood (UCB) is an alternate donor source with potentially increased morbidity in elderly patients. We evaluated outcomes in alternate donor sources, prior to the initiation of haploidentical transplantation at our institution, of matched unrelated donor (MUD) and UCB in elderly patients (mean age 64, range 60-75). One hundred and eighty-four patients were included (MRD: 57; MUD: 69; UCB: 58). There was no difference in acute or chronic graft versus host disease among donor sources (all p > .05). In this high-risk population, 128 (70%) had either a high disease risk index or high (>2) comorbidity index. Median progression free survival (PFS) was lowest among UCB (5.5 months; 95% CI 2.8-9.4) and MUD (5.6 months; 95% CI 3.7-17.7) as compared to MRD (18.3 months; 95% CI 8.4-64.8). On multivariable analysis, the rate of mortality was higher for UCB than MRD patients (1.88, 95% CI 1.04 – 3.37), but there was no difference between UCB and MUD (p = .61) or between MUD and MRD (p = .25). Conclusions were similar for PFS. Our experience shows that even in this high-risk elderly cohort, UCB continues to be a viable alternate donor source.

Sign in / Sign up

Export Citation Format

Share Document