Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder

2017 ◽  
Vol 329 ◽  
pp. 215-220 ◽  
Author(s):  
Maria Morena ◽  
Andrea Berardi ◽  
Andrea Peloso ◽  
Daniela Valeri ◽  
Maura Palmery ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Consolidation ◽  
Stress Disorder ◽  
Emotional Memory ◽  
Post Traumatic Stress ◽  
Post Traumatic

Emotional memory processing in post‐traumatic stress disorder affected Colombian youth

2020 ◽  
Author(s):  
Ivette Noriega ◽  
Elizabeth Trejos‐Castillo ◽  
Yoojin Chae ◽  
Liliana Calderon‐Delgado ◽  
Mauricio Barrera‐Valencia ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Emotional Memory ◽  
Post Traumatic Stress ◽  
Memory Processing ◽  
Post Traumatic

scholarly journals Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder

2021 ◽  
Author(s):  
Anna C van der Heijden ◽  
Winni F Hofman ◽  
Marieke de Boer ◽  
Mirjam J Nijdam ◽  
Hein JF van Marle ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Consolidation ◽  
Stress Disorder ◽  
Detection Method ◽  
Sleep Problems ◽  
Post Traumatic Stress ◽  
Spindle Activity ◽  
Post Traumatic ◽  
Intrusive Memory

Devastating and persisting traumatic memories are a central symptom of post-traumatic stress disorder (PTSD). Sleep problems are highly co-occurrent with PTSD and intertwined with its etiology. Notably, sleep hosts memory consolidation processes, supported by sleep spindles (11-16 Hz). Here we assess the hypothesis that intrusive memory symptoms in PTSD may arise from excessive memory consolidation, reflected in exaggerated spindling. We use a newly developed spindle detection method, entailing minimal assumptions regarding spindle phenotype, to assess spindle activity in PTSD patients and traumatized controls (n=2x14, matched on gender). Our results show increased spindle activity in PTSD, which positively correlates with daytime intrusive memory symptoms. Together, these findings provide a putative mechanism through which profound sleep disturbance in PTSD may contribute to memory problems. Due to its uniform and unbiased approach, the new, minimal assumption spindle detection method seems a promising tool to detect aberrant spindling in psychiatric disorders.

scholarly journals Neuroimaging findings in post-traumatic stress disorder

2002 ◽  
Vol 181 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Alastair M. Hull
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Psychological Trauma ◽  
Emotional Memory ◽  
Hippocampal Volume ◽  
Post Traumatic Stress ◽  
Functional Changes ◽  
Secondary Sources ◽  
Post Traumatic

BackgroundFindings from neuroimaging studies complement our understanding of the wide-ranging neurobiological changes in trauma survivors who develop post-traumatic stress disorder (PTSD).AimsTo determine whether neuroimaging studies had identified structural and functional changes specific to PTSD.MethodA review of all functional and structural neuroimaging studies of subjects with PTSD was carried out. Studies were identified using general medical and specific traumatic stress databases and paper searches of current contents and other secondary sources.ResultsThe most replicated structural finding is hippocampal volume reduction, which may limitthe proper evaluation and categorisation of experience. Replicated localised functional changes include increased activation ofthe amygdala after symptom provocation (which may reflect its role in emotional memory) and decreased activity of Broca's area at the same time (which may explain the difficulty patients have in labelling their experiences).ConclusionsEvidence from neuroimaging studies has suggested areas ofthe brain that may be damaged by psychological trauma. The clinical implications ofthese neuroimaging findings need to be investigated further because they challenge traditional therapeutic approaches.

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