Protein disulfide isomerase, a multifunctional protein chaperone, shows copper-binding activity

2003 ◽  
Vol 311 (2) ◽  
pp. 405-414 ◽  
Author(s):  
Suree Narindrasorasak ◽  
Ping Yao ◽  
Bibudhendra Sarkar
Keyword(s):  
Protein Disulfide Isomerase ◽  
Binding Activity ◽  
Copper Binding ◽  
Multifunctional Protein ◽  
Disulfide Isomerase ◽  
Protein Chaperone ◽  
Protein Disulfide

scholarly journals Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation

Blood ◽  
2013 ◽  
Vol 121 (19) ◽  
pp. 3789-3800 ◽  
Author(s):  
Eunsil Hahm ◽  
Jing Li ◽  
Kyungho Kim ◽  
Sungjin Huh ◽  
Snezna Rogelj ◽  
...  
Keyword(s):  
Protein Disulfide Isomerase ◽  
Vascular Inflammation ◽  
Binding Activity ◽  
Neutrophil Recruitment ◽  
Disulfide Isomerase ◽  
Isomerase Activity ◽  
Key Points ◽  
Protein Disulfide ◽  
Ligand Binding Activity ◽  
Neutrophil Surface

Key Points This work is the first identification of a neutrophil surface thiol isomerase regulating adhesive function of αMβ2 integrin. PDI is required for neutrophil recruitment during vascular inflammation and its isomerase activity is critical for the regulatory effect.

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