Polyethylenimine (PEI)-modified poly (lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with tumor-homing bacteria facilitate high intensity focused ultrasound-mediated tumor ablation

2021 ◽  
Vol 571 ◽  
pp. 104-109
Author(s):  
Disen Wang ◽  
Fujie Jiang ◽  
Lu Wang ◽  
Yu Tang ◽  
Zhong Zhang ◽  
...  
Keyword(s):  
High Intensity ◽  
Glycolic Acid ◽  
Focused Ultrasound ◽  
Plga Nanoparticles ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
Tumor Homing

scholarly journals Novel Therapeutic Method for Unresectable Pancreatic Cancer-The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy

2021 ◽  
Vol 28 (6) ◽  
pp. 4845-4861
Author(s):  
Atsushi Sofuni ◽  
Yasutsugu Asai ◽  
Takayoshi Tsuchiya ◽  
Kentaro Ishii ◽  
Reina Tanaka ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Symptom Relief ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
Therapeutic Effects ◽  
Unresectable Pancreatic Cancer ◽  
Advanced Therapy ◽  
The Impact

High-intensity focused ultrasound (HIFU) is a novel advanced therapy for unresectable pancreatic cancer (PC). HIFU therapy with chemotherapy is being promoted as a novel method to control local advancement by tumor ablation. We evaluated the therapeutic effects of HIFU therapy in locally advanced and metastatic PC. PC patients were treated with HIFU as an optional local therapy and systemic chemotherapy. The FEP-BY02 (Yuande Bio-Medical Engineering) HIFU device was used under ultrasound guidance. Of 176 PC patients, 89 cases were Stage III and 87 were Stage IV. The rate of complete tumor ablation was 90.3%, while that of symptom relief was 63.8%. The effectiveness on the primary lesions were as follows: complete response (CR): n = 0, partial response (PR): n = 21, stable disease (SD): n = 105, and progressive disease (PD): n = 47; the primary disease control rate was 71.0%. Eight patients underwent surgery. The median survival time (MST) after diagnosis for HIFU with chemotherapy compared to chemotherapy alone (100 patients in our hospital) was 772.3 vs. 346.6 days (p < 0.001). Compared with chemotherapy alone, the combination of HIFU therapy and chemotherapy demonstrated significant prolongation of prognosis. This study suggests that HIFU therapy has the potential to be a novel combination therapy for unresectable PC.

Liver Tumor Ablation with High-Intensity Focused Ultrasound

1993 ◽  
Vol 10 (02) ◽  
pp. 125-131 ◽  
Author(s):  
Kenyon Kopecky ◽  
Rong Yang ◽  
Narendra Sanghvi ◽  
Frederick Rescorla
Keyword(s):  
Liver Tumor ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound

scholarly journals Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation

Theranostics ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 562-572 ◽  
Author(s):  
Soo Hyun Shin ◽  
Eun-Joo Park ◽  
Changki Min ◽  
Sun Il Choi ◽  
Soyeon Jeon ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
19F Mri

scholarly journals Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation

2014 ◽  
Vol 37 (1) ◽  
pp. 174-177 ◽  
Author(s):  
Nobuhito Hamano ◽  
Yoichi Negishi ◽  
Kyohei Takatori ◽  
Yoko Endo-Takahashi ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
High Intensity ◽  
Antitumor Effect ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound

scholarly journals Factors Affecting Tumor Ablation during High Intensity Focused Ultrasound Treatment

Gut and Liver ◽  
2014 ◽  
Vol 8 (4) ◽  
pp. 433-437 ◽  
Author(s):  
Aizan Hassanuddin ◽  
Jun-Ho Choi ◽  
Dong-Wan Seo ◽  
Choong Heon Ryu ◽  
Su-Hui Kim ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Treatment ◽  
Factors Affecting

Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound

2015 ◽  
Vol 18 (4) ◽  
pp. 1050-1071 ◽  
Author(s):  
Maxim Solovchuk ◽  
Tony Wen-Hann Sheu ◽  
Marc Thiriet
Keyword(s):  
Blood Vessel ◽  
Treatment Planning ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Treatment Time ◽  
Acoustic Streaming ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Physical Fields

AbstractHigh intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.

scholarly journals Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies

2016 ◽  
Vol 66 (2) ◽  
pp. 247-258 ◽  
Author(s):  
Renske J. E. van den Bijgaart ◽  
Dylan C. Eikelenboom ◽  
Martijn Hoogenboom ◽  
Jurgen J. Fütterer ◽  
Martijn H. den Brok ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
High Intensity Focused Ultrasound ◽  
Combination Strategies
Sign in / Sign up

Export Citation Format

Share Document