Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1

Biochemical Pharmacology ◽

10.1016/j.bcp.2020.113987 ◽

2020 ◽

Vol 177 ◽

pp. 113987

Author(s):

Michele Biagioli ◽

Adriana Carino ◽

Silvia Marchianò ◽

Rosalinda Roselli ◽

Cristina Di Giorgio ◽

...

Keyword(s):

Bile Acid ◽

Acid Receptor ◽

Cysteinyl Leukotriene ◽

Bile Acid Receptor ◽

Leukotriene Receptor ◽

Cysteinyl Leukotriene Receptor

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Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01078 ◽

2021 ◽

Author(s):

Bianca Fiorillo ◽

Valentina Sepe ◽

Paolo Conflitti ◽

Rosalinda Roselli ◽

Michele Biagioli ◽

...

Keyword(s):

Bile Acid ◽

G Protein ◽

Structural Basis ◽

Acid Receptor ◽

Cysteinyl Leukotriene ◽

Bile Acid Receptor ◽

Leukotriene Receptor ◽

Cysteinyl Leukotriene Receptor ◽

G Protein Coupled

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Differential regulation of G-protein coupled bile acid receptor (Gpbar-1) by Sp1/KLF5 family transcription factors

Zeitschrift für Gastroenterologie ◽

10.1055/s-0035-1567990 ◽

2015 ◽

Vol 53 (12) ◽

Author(s):

C Chintalapati ◽

C Wöhler ◽

C Ehlting ◽

J Bode ◽

D Häussinger ◽

...

Keyword(s):

Transcription Factors ◽

Bile Acid ◽

G Protein ◽

Differential Regulation ◽

Acid Receptor ◽

Bile Acid Receptor ◽

G Protein Coupled

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The membrane-bound bile acid receptor (TGR5) controls the immune response against Listeria monocytogenes

Zeitschrift für Gastroenterologie ◽

10.1055/s-0036-1597451 ◽

2016 ◽

Vol 54 (12) ◽

pp. 1343-1404

Author(s):

M Reich ◽

P Lang ◽

D Häussinger ◽

V Keitel

Keyword(s):

Immune Response ◽

Bile Acid ◽

Listeria Monocytogenes ◽

Acid Receptor ◽

Membrane Bound ◽

Bile Acid Receptor

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Faculty Opinions recommendation of Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031130.363652 ◽

2006 ◽

Author(s):

Paul Webb

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Acid Receptor ◽

Bile Acid Receptor

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Faculty Opinions recommendation of Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1068778.522648 ◽

2007 ◽

Author(s):

Meenakshisundaram Ananthanarayanan

Keyword(s):

Bile Acid ◽

Liver Tumors ◽

Farnesoid X Receptor ◽

Acid Receptor ◽

Bile Acid Receptor

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Faculty Opinions recommendation of Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.720618866.793516747 ◽

2016 ◽

Author(s):

Robin Spiller

Keyword(s):

Bile Acid ◽

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Acid Receptor ◽

Bile Acid Receptor

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Faculty Opinions recommendation of Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726155622.793515325 ◽

2016 ◽

Author(s):

Bruno Stieger

Keyword(s):

Bile Acid ◽

Intrahepatic Cholestasis ◽

Progressive Familial Intrahepatic Cholestasis ◽

Acid Receptor ◽

Bile Acid Receptor

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Faculty Opinions recommendation of Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726155622.793514873 ◽

2016 ◽

Author(s):

Meenakshisundaram Ananthanarayanan

Keyword(s):

Bile Acid ◽

Intrahepatic Cholestasis ◽

Progressive Familial Intrahepatic Cholestasis ◽

Acid Receptor ◽

Bile Acid Receptor

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A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.111.186031 ◽

2011 ◽

Vol 339 (3) ◽

pp. 768-778 ◽

Cited By ~ 40

Author(s):

Nathan C. Ni ◽

Dong Yan ◽

Laurel L. Ballantyne ◽

Alma Barajas-Espinosa ◽

Tim St. Amand ◽

...

Keyword(s):

Myocardial Ischemia ◽

Reperfusion Injury ◽

Vascular Permeability ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Cysteinyl Leukotriene ◽

Myocardial Ischemia Reperfusion Injury ◽

Leukotriene Receptor ◽

Myocardial Ischemia Reperfusion ◽

Cysteinyl Leukotriene Receptor

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Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA) (responsiveness to montelukast on EIA in children)

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2007.02795.x ◽

2007 ◽

Vol 0 (0) ◽

pp. 070831211107004-??? ◽

Cited By ~ 1

Author(s):

S.-Y. Lee ◽

H.-B. Kim ◽

J.-H. Kim ◽

B.-S. Kim ◽

M.-J. Kang ◽

...

Keyword(s):

Immunoglobulin E ◽

Bronchial Hyperresponsiveness ◽

Leukotriene C4 ◽

Korean Children ◽

Cysteinyl Leukotriene ◽

Leukotriene Receptor ◽

Cysteinyl Leukotriene Receptor ◽

Exercise Induced ◽

Total Immunoglobulin ◽

Leukotriene C4 Synthase

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