Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states

Biochimie ◽  
2006 ◽  
Vol 88 (5) ◽  
pp. 543-549 ◽  
Author(s):  
M.T. Murakami ◽  
A. Gabdoulkhakov ◽  
N. Genov ◽  
A.C.O. Cintra ◽  
C. Betzel ◽  
...  
Keyword(s):  
High Resolution ◽  
Phospholipase A2 ◽  
Crystal Structures ◽  
Metal Ion ◽  
Bound States ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Phospholipases A2

scholarly journals Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde

2003 ◽  
Vol 59 (11) ◽  
pp. o629-o633 ◽  
Author(s):  
Paul V. Bernhardt ◽  
Lorraine M. Caldwell ◽  
David B. Lovejoy ◽  
Des R. Richardson
Keyword(s):  
Dimethyl Sulfoxide ◽  
Crystal Structures ◽  
Metal Ion ◽  
Antitumour Activity ◽  
Donor Ligands ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
X Ray ◽  
Conformational Variations ◽  
Optimum Conformation

The X-ray crystal structures are reported of four novel and potentially O,N,S-tridentate donor ligands that demonstrate antitumour activity. These ligands are 1-[(4-methylthiosemicarbazono)methyl]-2-naphthol, C13H13N3OS, (III), 1-[(4-ethylthiosemicarbazono)methyl]-2-naphthol, C14H15N3OS, (IV), 1-[(4-phenylthiosemicarbazono)methyl]-2-naphthol, C18H15N3OS, (V), and 1-[(4,4-dimethylthiosemicarbazono)methyl]-2-naphthol dimethyl sulfoxide solvate, C14H15N3OS·C2H6OS, (VI). These chelators are N4-substituted thiosemicarbazones, each based on the same parent aldehyde, namely 2-zhydroxynaphthalene-1-carboxaldehyde isonicotinoylhydrazone. Conformational variations within this series are discussed in relation to the optimum conformation for metal-ion binding.

Metal ion binding by amino acids. Preparation and crystal structures of magnesium, strontium, and bariumL-glutamate hydrates

1989 ◽  
Vol 122 (8) ◽  
pp. 1433-1438 ◽  
Author(s):  
Hubert Schmidbaur ◽  
Ina Bach ◽  
Dallas L. Wilkinson ◽  
Gerhard Müller
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Metal Ion ◽  
Ion Binding ◽  
Metal Ion Binding

Metal ion binding by amino acids. Preparation and crystal structures of two calciumL-asparatate hydrates

1989 ◽  
Vol 122 (8) ◽  
pp. 1439-1444 ◽  
Author(s):  
Hubert Schmidbaur ◽  
Ina Bach ◽  
Dallas L. Wilkinson ◽  
Gerhard Müller
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Metal Ion ◽  
Ion Binding ◽  
Metal Ion Binding

Photophysical Characterisation, Metal Ion Binding and Enantiomeric Recognition of Chiral Ligands Containing Phenazine Fluorophore

2004 ◽  
Vol 69 (4) ◽  
pp. 885-896 ◽  
Author(s):  
Luisa Stella Dolci ◽  
Péter Huszthy ◽  
Erika Samu ◽  
Marco Montalti ◽  
Luca Prodi ◽  
...  
Keyword(s):  
Metal Ion ◽  
Photophysical Properties ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Ammonium Ions ◽  
Enantiomerically Pure ◽  
Binding Process ◽  
High Affinity ◽  
Enantiomeric Recognition ◽  
Chiral Species

Enantiomerically pure dimethyl- and diisobutyl-substituted phenazino-18-crown-6 ligands bind metal and ammonium ions and also primary aralkylammonium perchlorates in acetonitrile with high affinity, causing pronounced changes in their luminescence properties. In addition, they show enantioselectivity towards chiral primary aralkylammonium perchlorates. The possibility to monitor the binding process by photoluminescence spectroscopy can gain ground for the design of very efficient enantioselective chemosensors for chiral species. The observed changes in the photophysical properties are also an important tool for understanding the interactions present in the adduct.

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