Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair

Biomaterials ◽  
2008 ◽  
Vol 29 (26) ◽  
pp. 3547-3556 ◽  
Author(s):  
Hao-Ji Wei ◽  
Chun-Hung Chen ◽  
Wen-Yu Lee ◽  
Iwen Chiu ◽  
Shiaw-Min Hwang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Myocardial Repair ◽  
Cardiac Patch

Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair

2020 ◽  
Vol 235 (11) ◽  
pp. 8010-8022 ◽  
Author(s):  
Xiaolin Liu ◽  
Xin Li ◽  
Wenwu Zhu ◽  
Yuelin Zhang ◽  
Yimei Hong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Myocardial Repair

Possibilities and limitations for co-transplantation of cardiac atrial appendage stem cells and mesenchymal stem cells for myocardial repair

2016 ◽  
Vol 203 ◽  
pp. 1155-1156 ◽  
Author(s):  
Yanick Fanton ◽  
Boris Robic ◽  
Jean-Luc Rummens ◽  
Annick Daniëls ◽  
Severina Windmolders ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Atrial Appendage ◽  
Myocardial Repair

scholarly journals In vivo priming of human mesenchymal stem cells with hepatocyte growth factor–engineered mesenchymal stem cells promotes therapeutic potential for cardiac repair

2020 ◽  
Vol 6 (13) ◽  
pp. eaay6994 ◽  
Author(s):  
Bong-Woo Park ◽  
Soo-Hyun Jung ◽  
Sanskrita Das ◽  
Soon Min Lee ◽  
Jae-Hyun Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Therapeutic Potential ◽  
Cardiac Repair ◽  
Vascular Regeneration ◽  
Cardiac Patch ◽  
Hepatocyte Growth

The clinical use of human bone marrow–derived mesenchymal stem cells (BM-MSCs) has been hampered by their poor performance after transplantation into failing hearts. Here, to improve the therapeutic potential of BM-MSCs, we developed a strategy termed in vivo priming in which BM-MSCs are primed in vivo in myocardial infarction (MI)–induced hearts through genetically engineered hepatocyte growth factor–expressing MSCs (HGF-eMSCs) that are encapsulated within an epicardially implanted 3D cardiac patch. Primed BM-MSCs through HGF-eMSCs exhibited improved vasculogenic potential and cell viability, which ultimately enhanced vascular regeneration and restored cardiac function to the MI hearts. Histological analyses further demonstrated that the primed BM-MSCs survived longer within a cardiac patch and conferred cardioprotection evidenced by substantially higher numbers of viable cardiomyocytes in the MI hearts. These results provide compelling evidence that this in vivo priming strategy can be an effective means to enhance the cardiac repair of MI hearts.

scholarly journals A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates

2016 ◽  
Vol 118 (6) ◽  
pp. 970-983 ◽  
Author(s):  
Xinyang Hu ◽  
Yinchuan Xu ◽  
Zhiwei Zhong ◽  
Yan Wu ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Large Scale ◽  
Nonhuman Primates ◽  
Myocardial Repair
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