Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents

2017 ◽  
Vol 74 ◽  
pp. 82-90 ◽  
Author(s):  
Mohamed A. Abdelgawad ◽  
Rania B. Bakr ◽  
Hany A. Omar
Keyword(s):  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

Naphthoflavones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation

2016 ◽  
Vol 16 (7) ◽  
pp. 881-890 ◽  
Author(s):  
Dinesh Kumar ◽  
Onkar Singh ◽  
Kunal Nepali ◽  
PMS Bedi ◽  
Arem Qayum ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity

2010 ◽  
Vol 33 (7) ◽  
pp. 971-980 ◽  
Author(s):  
Priyal Jain ◽  
Prakash Kumar Sharma ◽  
Harish Rajak ◽  
Rajesh Singh Pawar ◽  
Umesh Kumar Patil ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

2010 ◽  
Vol 20 (9) ◽  
pp. 2733-2739 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Carlota Lopez Cara ◽  
Maria Dora Carrion ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34266-34274 ◽  
Author(s):  
Lei Zhang ◽  
Ying Rong ◽  
Jie Zheng ◽  
Chengli Yang ◽  
Yongzheng Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

Conjugate S1 exhibited potential antiproliferative activity against multi-drug resistant leukemia cells.

scholarly journals Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1655-1658 ◽  
Author(s):  
Zhong-Hua Li ◽  
Xue-Qi Liu ◽  
Peng-Fei Geng ◽  
Jin-Lian Ma ◽  
Tao-Qian Zhao ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivative ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Potent Inhibition ◽  
Synthesis And Biological Evaluation

The thiazolo[5,4-d]pyrimidine derivative 7i exhibited potent inhibition against MGC-803 and HGC-27 with IC50 values of 4.64 and 5.07 μM, respectively and around 12-fold selectivity between MGC-803 and GES-1.

Sign in / Sign up

Export Citation Format

Share Document