Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists

Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: rational design, synthesis and biological evaluation

Amino Acids ◽

10.1007/s00726-010-0651-y ◽

2010 ◽

Vol 40 (2) ◽

pp. 411-420 ◽

Cited By ~ 8

Author(s):

George Agelis ◽

Amalia Resvani ◽

Minos-Timotheos Matsoukas ◽

Theodore Tselios ◽

Konstantinos Kelaidonis ◽

...

Keyword(s):

Rational Design ◽

Biological Evaluation ◽

At1 Receptor ◽

Urocanic Acid ◽

Ang Ii ◽

Receptor Antagonists ◽

Design Synthesis ◽

Angiotensin II – AT1 receptor antagonists: Design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2007.11.008 ◽

2008 ◽

Vol 43 (9) ◽

pp. 1808-1812 ◽

Cited By ~ 37

Author(s):

Dhvanit I. Shah ◽

Manu Sharma ◽

Yogita Bansal ◽

Gulshan Bansal ◽

Manjeet Singh

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Benzimidazole Derivatives ◽

Receptor Antagonists ◽

Design Synthesis ◽

Design, synthesis, pharmacological evaluation and in silico ADMET prediction of novel substituted benzimidazole derivatives as angiotensin II–AT1 receptor antagonists based on predictive 3D QSAR models

SAR and QSAR in Environmental Research ◽

10.1080/1062936x.2013.868825 ◽

2014 ◽

Vol 25 (2) ◽

pp. 117-146 ◽

Cited By ~ 6

Author(s):

V.K. Vyas ◽

N. Gupta ◽

M. Ghate ◽

S. Patel

Keyword(s):

Angiotensin Ii ◽

In Silico ◽

3D Qsar ◽

At1 Receptor ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Pharmacological Evaluation ◽

In Silico Admet ◽

Qsar Models

Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-014-1095-9 ◽

2014 ◽

Vol 24 (1) ◽

pp. 442-458 ◽

Cited By ~ 1

Author(s):

Mohamed A. H. Ismail ◽

Mohamed Nabil Aboul-Enein ◽

Aida Abd ElSatar El-Azzouny ◽

Khaled A. M. Abouzid ◽

Nasser S. M. Ismail

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.05.056 ◽

2012 ◽

Vol 20 (14) ◽

pp. 4208-4216 ◽

Cited By ~ 20

Author(s):

Jun Zhang ◽

Jin-Liang Wang ◽

Zhi-Ming Zhou ◽

Zhi-Huai Li ◽

Wei-Zhe Xue ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

ChemInform Abstract: Computer-Based Drug Design, Synthesis and Biological Evaluation of New Pyrimidinone Derivatives Linked to Arylpiperazine and 2′-Carbethoxy-biphenylmethyl Moieties as α1-Adrenoceptor Antagonists and Angiotensin II AT1 Receptor Antagoni

ChemInform ◽

10.1002/chin.201109171 ◽

2011 ◽

Vol 42 (9) ◽

pp. no-no

Author(s):

M. A. H. Ismail ◽

D. A. Abou El Ella ◽

K. A. M. Abouzid ◽

G. H. A. Al-Ansary

Keyword(s):

Angiotensin Ii ◽

Drug Design ◽

Biological Evaluation ◽

At1 Receptor ◽

Design Synthesis ◽

Computer Based ◽

Synthesis of N-Alkyl-1,2,4-oxadiazinones as Angiotensin-II (AT1) Receptor Antagonists

Heterocycles ◽

10.3987/com-92-6263 ◽

1993 ◽

Vol 36 (5) ◽

pp. 1027 ◽

Cited By ~ 12

Author(s):

Harold N. Weller ◽

Arthur V. Miller ◽

Kenneth E. J. Dickinson ◽

S. Anders Hedberg ◽

Carol L. Delaney ◽

...

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

Molecular modelling studies for the discovery of new substituted pyridines derivatives with angiotensin II AT1 receptor antagonists

Interdisciplinary Sciences Computational Life Sciences ◽

10.1007/s12539-013-0201-x ◽

2014 ◽

Vol 6 (3) ◽

pp. 197-207 ◽

Cited By ~ 5

Author(s):

Mukesh C. Sharma

Keyword(s):

Angiotensin Ii ◽

Molecular Modelling ◽

At1 Receptor ◽

Receptor Antagonists ◽

Molecular Modelling Studies ◽

Substituted Pyridines ◽

Modelling Studies

N-(2,7-Dimethyl-2-alkyl-2H-chromen-6-yl)sulfonamide derivatives as selective serotonin 5-HT6 receptor antagonists: design, synthesis, and biological evaluation

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131417 ◽

2021 ◽

pp. 131417

Author(s):

Aizhan Abdildinova ◽

Young Chang Kim ◽

Gee-Hyung Lee ◽

Woo-Kyu Park ◽

Heeyeong Cho ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Serotonin ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.011 ◽

2012 ◽

Vol 20 (15) ◽

pp. 4661-4667 ◽

Cited By ~ 18

Author(s):

Renren Bai ◽

Zhen Wei ◽

Jie Liu ◽

Weijia Xie ◽

Hequan Yao ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Endothelin A Receptor ◽

Endothelin A ◽