Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors

2020 ◽  
Vol 105 ◽  
pp. 104399
Author(s):  
Khaled El-Adl ◽  
Abdel-Ghany A. El-Helby ◽  
Helmy Sakr ◽  
Alaa Elwan
Keyword(s):  
Molecular Docking ◽  
Topoisomerase Ii ◽  
Design Synthesis ◽  
Dna Intercalators ◽  
Topoisomerase Ii Inhibitors ◽  
Quinoxaline Derivatives

[1,2,4]Triazolo[4,3-a]quinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline-1-thiol-derived DNA intercalators: design, synthesis, molecular docking, in silico ADMET profiles and anti-proliferative evaluations

2021 ◽  
Author(s):  
Khaled El-Adl ◽  
Abdel-Ghany A. El-Helby ◽  
Helmy Sakr ◽  
Alaa Elwan
Keyword(s):  
Molecular Docking ◽  
Anticancer Agents ◽  
In Silico ◽  
Dna Intercalation ◽  
Design Synthesis ◽  
Dna Intercalators ◽  
In Silico Admet ◽  
Quinoxaline Derivatives ◽  
Hct 116 ◽  
Mcf 7

In view of their DNA intercalation activities as anticancer agents, 17 novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 cells.

Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors

2021 ◽  
Author(s):  
Helmy Sakr ◽  
Rezk R. Ayyad ◽  
Ali A. El‐Helby ◽  
Mohamed M. Khalifa ◽  
Hazem A. Mahdy
Keyword(s):  
Topoisomerase Ii ◽  
Dna Intercalators ◽  
Topoisomerase Ii Inhibitors

Design, synthesis and molecular docking of new [1,2,4] triazolo[4,3-a]quinoxaline derivatives as anticancer agents targeting VEGFR-2 kinase

2021 ◽  
Author(s):  
Nawaf A. Alsaif ◽  
Alaa Elwan ◽  
Mohammed M. Alanazi ◽  
Ahmad J. Obaidullah ◽  
Wael A. Alanazi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Anticancer Agents ◽  
Design Synthesis ◽  
Quinoxaline Derivatives
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