Biocatalytic One Pot Three Component Approach: Facile Synthesis, Characterization, Molecular modelling and Hypoglycemic Studies of New Thiazolidinedione Festooned Quinoline Analogues Catalyzed by Alkaline Protease from Aspergillus Niger

2021 ◽  
pp. 105533
Author(s):  
Gangadhara Angajala ◽  
Valmiki Aruna ◽  
Pasupala Pavan ◽  
Pulikanti Guruprasad Reddy
Keyword(s):  
Aspergillus Niger ◽  
Molecular Modelling ◽  
Alkaline Protease ◽  
Facile Synthesis ◽  
One Pot ◽  
Component Approach

scholarly journals Structure and conformational analysis of spiroketals from 6-O-methyl-9(E)-hydroxyiminoerythronolide A

2015 ◽  
Vol 11 ◽  
pp. 1447-1457 ◽  
Author(s):  
Ana Čikoš ◽  
Irena Ćaleta ◽  
Dinko Žiher ◽  
Mark B Vine ◽  
Ivaylo J Elenkov ◽  
...  
Keyword(s):  
Double Bond ◽  
Nmr Spectroscopy ◽  
Conformational Analysis ◽  
Reaction Kinetics ◽  
Molecular Modelling ◽  
Lactone Ring ◽  
Facile Synthesis ◽  
One Pot ◽  
Unexpected Formation ◽  
Spontaneous Change

Three novel spiroketals were prepared by a one-pot transformation of 6-O-methyl-9(E)-hydroxyiminoerythronolide A. We present the formation of a [4.5]spiroketal moiety within the macrolide lactone ring, but also the unexpected formation of a 10-C=11-C double bond and spontaneous change of stereochemistry at position 8-C. As a result, a thermodynamically stable structure was obtained. The structures of two new diastereomeric, unsaturated spiroketals, their configurations and conformations, were determined by means of NMR spectroscopy and molecular modelling. The reaction kinetics and mechanistic aspects of this transformation are discussed. These rearrangements provide a facile synthesis of novel macrolide scaffolds.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

Facile Synthesis of Nitrogen-Doped [(6.)m8]nCyclacene Carbon Nanobelts by a One-Pot Self-Condensation Reaction

2021 ◽  
Vol 143 (7) ◽  
pp. 2716-2721
Author(s):  
Jun Zhu ◽  
Yi Han ◽  
Yong Ni ◽  
Guangwu Li ◽  
Jishan Wu
Keyword(s):  
Condensation Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Nitrogen Doped

ChemInform Abstract: Facile Synthesis of Multifunctional Pyrrole[2,1-a]isoquinolin-3(2H)-ones via Sulfa-Michael-Triggered One-Pot Reactions.

ChemInform ◽  
2016 ◽  
Vol 47 (25) ◽  
Author(s):  
Tian-You Qin ◽  
Lu Cheng ◽  
Ho-Chol Jang ◽  
Sean Xiao-An Zhang ◽  
Wei-Wei Liao
Keyword(s):  
Facile Synthesis ◽  
One Pot

A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 67281-67289 ◽  
Author(s):  
Ali Khalafi-Nezhad ◽  
Mohsen Shekouhy ◽  
Hashem Sharghi ◽  
Jasem Aboonajmi ◽  
Abdolkarim Zare
Keyword(s):  
Primary Amines ◽  
One Pot ◽  
One Pot Condensation ◽  
Component Approach ◽  
The One ◽  
Tetrasubstituted Imidazoles

A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described.

One-pot, facile synthesis of well-defined molecular brush copolymers by a tandem RAFT and ROMP, “Grafting-through” strategy

2012 ◽  
Vol 50 (9) ◽  
pp. 1681-1688 ◽  
Author(s):  
Ang Li ◽  
Jun Ma ◽  
Guorong Sun ◽  
Zhou Li ◽  
Sangho Cho ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
One Pot ◽  
Grafting Through

Facile Synthesis of Fe2O3Nanocrystals without Fe(CO)5Precursor and One-Pot Synthesis of Highly Fluorescent Fe2O3-CdSe Nanocomposites

2009 ◽  
Vol 21 (8) ◽  
pp. 869-873 ◽  
Author(s):  
Chung Yen Ang ◽  
Louise Giam ◽  
Zheng Ming Chan ◽  
Alex W. H. Lin ◽  
Hongwei Gu ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
One Pot ◽  
One Pot Synthesis
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