Anatomic Abnormalities of the Anterior Cingulate Cortex Before Psychosis Onset: An MRI Study of Ultra-High-Risk Individuals

2008 ◽  
Vol 64 (9) ◽  
pp. 758-765 ◽  
Author(s):  
Alex Fornito ◽  
Alison R. Yung ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Barnaby Nelson ◽  
...  
2003 ◽  
Vol 182 (6) ◽  
pp. 518-524 ◽  
Author(s):  
Murat Yücel ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Geoffrey W. Stuart ◽  
Deidre J. Smith ◽  
...  

BackgroundThe anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder.AimsTo examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness.MethodMagnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features.ResultsCompared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness.ConclusionsAlthough ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.


2018 ◽  
Vol 83 (9) ◽  
pp. S181
Author(s):  
Hisham Ibrahim ◽  
Kulikova Alexandra ◽  
A. John Rush ◽  
E. Sherwood Brown

Author(s):  
Hicham M. Ibrahim ◽  
Alexandra Kulikova ◽  
Huy Ly ◽  
A. John Rush ◽  
E. Sherwood Brown

2012 ◽  
Vol 136 ◽  
pp. S298-S299
Author(s):  
Hvevoun Park ◽  
laeYeon Hwang ◽  
WiHoon Jung ◽  
Geumsook Shim ◽  
JoonHwan Jang ◽  
...  

2013 ◽  
Vol 150 (2-3) ◽  
pp. 512-518 ◽  
Author(s):  
Hye Youn Park ◽  
Jae Yeon Hwang ◽  
Wi Hoon Jung ◽  
Na Young Shin ◽  
Geumsook Shim ◽  
...  

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