Thermo-sensitive TRP channels in peripheral nerve injury: A review of their role in cold intolerance

2014 ◽  
Vol 67 (5) ◽  
pp. 591-599 ◽  
Author(s):  
S. Kambiz ◽  
L.S. Duraku ◽  
J.C. Holstege ◽  
S.E.R. Hovius ◽  
T.J.H. Ruigrok ◽  
...  
2020 ◽  
Vol 25 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Ernesta Magistroni ◽  
Giulia Parodi ◽  
Fabrizio Fop ◽  
Bruno Battiston ◽  
Lars B. Dahlin

2019 ◽  
Vol 42 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Franco Franchignoni ◽  
Ernesta Magistroni ◽  
Giulia Parodi ◽  
Giuseppe Massazza ◽  
Giorgio Ferriero ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-9
Author(s):  
Marcin Ceynowa ◽  
Tomasz Mazurek ◽  
Rafał Pankowski ◽  
Marek Rocławski ◽  
Mariusz Treder

The purpose of this study was to evaluate the ability to discriminate temperatures in patients following peripheral nerve injury. Knowing that temperature sensibility is mediated by different receptors, the scores were compared to other functional hand scores in order to determine whether the ability to discriminate temperatures is restored to a different extent compared with other commonly evaluated hand function modalities. The test was performed using the NTE-2 device (Physitemp Instruments Inc., 154 Huron Avenue, Clifton, New Jersey, USA). Out of 57 patients, 27 had normal thermal discrimination scores, and 9 could not tell the temperatures apart in the differences set on the measuring device. Overall, patients with better thermal discrimination had also better hand function as evaluated with different methods. However, some patients who did regain the ability to differentiate temperatures correctly did not have any measurable return of hand function in other tests. Thermal discrimination scores correlated similarly with different functional scores, except for vibration sensibility, which did not show any significant correlation. The development and severity of cold intolerance seem to be unrelated to temperature sense.


2020 ◽  
Vol 15 (6) ◽  
pp. 522-530
Author(s):  
Jiawei Shu ◽  
Feng Cheng ◽  
Zhe Gong ◽  
Liwei Ying ◽  
Chenggui Wang ◽  
...  

Spinal cord injury (SCI) is different from peripheral nerve injury; it results in devastating and permanent damage to the spine, leading to severe motor, sensory and autonomic dysfunction. SCI produces a complex microenvironment that can result in hemorrhage, inflammation and scar formation. Not only does it significantly limit regeneration, but it also challenges a multitude of transplantation strategies. In order to promote regeneration, researchers have recently begun to focus their attention on strategies that manipulate the complicated microenvironment produced by SCI. And some have achieved great therapeutic effects. Hence, reconstructing an appropriate microenvironment after transplantation could be a potential therapeutic solution for SCI. In this review, first, we aim to summarize the influential compositions of the microenvironment and their different effects on regeneration. Second, we highlight recent research that used various transplantation strategies to modulate different microenvironments produced by SCI in order to improve regeneration. Finally, we discuss future transplantation strategies regarding SCI.


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