Structure and in vitro antitumor activity evaluation of brominated diterpenes from the red alga Sphaerococcus coronopifolius

A novel alkaloid scaffold was designed through scaffold-hopping strategy based on the active pyrazines alkaloid isolated previously. A total of 25 derivatives were synthesized based on this scaffold and evaluated for their antitumor activities. Among all these tested compounds, 9f exhibited most excellent antitumor activities toward H460 cells, TMD-8 cells, and MV4-11 cells in vitro by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay with IC50 values of 29.8, 14.9, and 18.8 μM, respectively.

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ChemInform Abstract: New 6-Cyano-3-phenyl-1,2,3,4-tetrahydro-1,2-diazepin-5-ones: Synthesis and in vitro Antitumor Activity Evaluation.

ChemInform ◽

10.1002/chin.199210212 ◽

2010 ◽

Vol 23 (10) ◽

pp. no-no

Author(s):

V. DAL PIAZ ◽

G. CICIANI ◽

M. P. GIOVANNONI

Keyword(s):

Antitumor Activity ◽

Activity Evaluation

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Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation

Life Sciences ◽

10.1016/j.lfs.2020.117943 ◽

2020 ◽

Vol 256 ◽

pp. 117943

Author(s):

Fatemeh Madani ◽

Seyedeh Sara Esnaashari ◽

Maria Camilla Bergonzi ◽

Thomas J. Webster ◽

Husam M. Younes ◽

...

Keyword(s):

Antitumor Activity ◽

Plga Nanoparticles ◽

Formulation Development ◽

Activity Evaluation

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Preparation, characterization and in vitro antitumor activity evaluation of hyaluronic acid-alendronate-methotrexate nanoparticles

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.10.088 ◽

2021 ◽

Vol 166 ◽

pp. 71-79

Author(s):

Chunxia Gao ◽

Mengmeng Wang ◽

Peizhi Zhu ◽

Caifeng Yan

Keyword(s):

Hyaluronic Acid ◽

Antitumor Activity ◽

Activity Evaluation

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ChemInform Abstract: Synthesis and in vitro Antitumor Activity Evaluation of 1-Aryl-1H,3H-thiazolo[4,3-b]quinazolines.

ChemInform ◽

10.1002/chin.200115153 ◽

2001 ◽

Vol 32 (15) ◽

pp. no-no

Author(s):

Silvana Grasso ◽

Nicola Micale ◽

Anna-Maria Monforte ◽

Pietro Monforte ◽

Santina Polimeni ◽

...

Keyword(s):

Antitumor Activity ◽

Activity Evaluation

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Synthesis and antitumor activity evaluation of a novel porphyrin derivative for photodynamic therapy in vitro and in vivo

Tumor Biology ◽

10.1007/s13277-015-4576-7 ◽

2015 ◽

Vol 37 (5) ◽

pp. 6923-6933 ◽

Cited By ~ 6

Author(s):

Li-Jun Zhang ◽

Yi-Jia Yan ◽

Ping-Yong Liao ◽

Davor Margetic ◽

Li Wang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Antitumor Activity ◽

Porphyrin Derivative ◽

Activity Evaluation

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Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius

Marine Drugs ◽

10.3390/md18010029 ◽

2019 ◽

Vol 18 (1) ◽

pp. 29 ◽

Cited By ~ 1

Author(s):

Vangelis Smyrniotopoulos ◽

Anna Cláudia de Andrade Tomaz ◽

Maria de Fátima Vanderlei de Souza ◽

Emídio Vasconcelos Leitão da Cunha ◽

Robert Kiss ◽

...

Keyword(s):

Antitumor Activity ◽

Human Cancer ◽

Red Alga ◽

Ionian Sea ◽

Relative Configuration ◽

Human Cancer Cell Lines ◽

Spectroscopic Analyses ◽

Organic Extracts ◽

Ic50 Values

Eight new (1–8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively.

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