β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation

2017 ◽  
Vol 25 (20) ◽  
pp. 5613-5628 ◽  
Author(s):  
Barbara Männel ◽  
Harald Hübner ◽  
Dorothée Möller ◽  
Peter Gmeiner
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Pharmacological Evaluation ◽  
Partial Agonists ◽  
Dopamine D2

scholarly journals Active-State Model of a Dopamine D2 Receptor - Gαi Complex Stabilized by Aripiprazole-Type Partial Agonists

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100069 ◽  
Author(s):  
Ralf C. Kling ◽  
Nuska Tschammer ◽  
Harald Lanig ◽  
Timothy Clark ◽  
Peter Gmeiner
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Active State ◽  
State Model ◽  
Partial Agonists ◽  
Dopamine D2

Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties

2006 ◽  
Vol 546 (1-3) ◽  
pp. 88-94 ◽  
Author(s):  
Martyn D. Wood ◽  
Claire Scott ◽  
Kirsten Clarke ◽  
Julie Westaway ◽  
Ceri H. Davies ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Human Metabolite ◽  
Partial Agonists ◽  
Dopamine D2

Investigation of novel ropinirole analogues: synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

MedChemComm ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 891-898 ◽  
Author(s):  
Manuela Jörg ◽  
Agnieszka A. Kaczor ◽  
Frankie S. Mak ◽  
Kiew Ching K. Lee ◽  
Antti Poso ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Computational Analysis ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Pharmacological Evaluation ◽  
Dopamine D2 ◽  
Molecular Modeling Study ◽  
Modeling Study

This study includes the synthesis, pharmacological evaluation and molecular modeling study of novel ropinirole-based monovalent and homobivalent ligands.

Serotonergic agonists behave as partial agonists at the dopamine D2 receptor

Neuroreport ◽  
1999 ◽  
Vol 10 (3) ◽  
pp. 493-495 ◽  
Author(s):  
Ago Rinken ◽  
Sergi Ferré ◽  
Anton Terasmaa ◽  
Christer Owman ◽  
Kjell Fuxe
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Partial Agonists ◽  
Dopamine D2

Developing New Dopamine D2 Receptor Agonists and Partial Agonists for Parkinson’s Disease and Schizophrenia

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Thomas M. Keck ◽  
Catherine Nguyen ◽  
Emily Kurtyan ◽  
Bohn Stephanie ◽  
Raymond Crowthers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Agonists ◽  
Partial Agonists ◽  
Dopamine D2

Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581

2010 ◽  
Vol 20 (9) ◽  
pp. 2888-2891 ◽  
Author(s):  
Francine Pazini ◽  
Ricardo Menegatti ◽  
José R. Sabino ◽  
Carolina H. Andrade ◽  
Gilda Neves ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Pharmacological Evaluation ◽  
Dopamine D2 ◽  
Hydroxylated Metabolite
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