Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors

2018 ◽  
Vol 26 (12) ◽  
pp. 3217-3226 ◽  
Author(s):  
Wei Wang ◽  
Xiu Feng ◽  
Huan-Xiang Liu ◽  
Shi-Wu Chen ◽  
Ling Hui
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Biological Evaluation ◽  
Aurora Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors

2019 ◽  
Vol 29 (5) ◽  
pp. 694-699 ◽  
Author(s):  
You-Zhen Ma ◽  
Zhen-Bo Tang ◽  
Chun-Yan Sang ◽  
Zhi-Yuan Qi ◽  
Ling Hui ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Biological Evaluation ◽  
Aurora Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors

2020 ◽  
Vol 30 (3) ◽  
pp. 126885 ◽  
Author(s):  
Yu Xu ◽  
Shu-Yi Hao ◽  
Xiu-Juan Zhang ◽  
Wen-Bo Li ◽  
Xue-Peng Qiao ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors
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