Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide

2021 ◽  
pp. 116111
Author(s):  
Takuma Kato ◽  
Yuki Kita ◽  
Kazuki Iwanari ◽  
Akiko Asano ◽  
Makoto Oba ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ring Size ◽  
Disubstituted Amino Acids

Synthesis of a series of “cationic”, orthogonally protected, α, α-disubstituted amino acids

2005 ◽  
pp. 329-330
Author(s):  
T. S. Yokum ◽  
M. G. Bursavich ◽  
S. A. Piha-Paul ◽  
D. A. Hall ◽  
M. L. McLaughlin
Keyword(s):  
Amino Acids ◽  
Disubstituted Amino Acids

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters

2017 ◽  
Vol 25 (6) ◽  
pp. 1846-1851 ◽  
Author(s):  
Hiroko Yamashita ◽  
Takashi Misawa ◽  
Makoto Oba ◽  
Masakazu Tanaka ◽  
Mikihiko Naito ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Disubstituted Amino Acids

Pd-Catalyzed directedCH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

2019 ◽  
Vol 17 (17) ◽  
pp. 4342-4349 ◽  
Author(s):  
Valeriia Hutskalova ◽  
Pavel K. Mykhailiuk
Keyword(s):  
Amino Acids ◽  
Systematic Study ◽  
Ring Size ◽  
Directing Group ◽  
First Time ◽  
Cyclic Amino Acids

A systematic study on the directed Pd-catalyzed (hetero)arylation of 26 substituted cyclic α-amino acids at the C(3)-atom was performed. For the first time, the 7- and 8-membered cyclic amino acids were introduced to C–H activation. 8–Aminoquinoline was used as a directing group.

Ethyl Nitroacetate as a Useful Synthon for the Synthesis of Orthogonally Protected, Polyfunctional C[α,α]- Disubstituted Amino Acids

ChemInform ◽  
2003 ◽  
Vol 34 (21) ◽  
Author(s):  
Yanwen Fu ◽  
Lars G. J. Hammarstrom ◽  
Tod J. Miller ◽  
Mark L. McLaughlin ◽  
Robert P. Hammer
Keyword(s):  
Amino Acids ◽  
Ethyl Nitroacetate ◽  
Disubstituted Amino Acids
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