Docking and Mutagenesis Studies Lead to Improved Inhibitor Development of ML355 for Human Platelet 12-lipoxygenase

2021 ◽  
pp. 116347
Author(s):  
Wan-Chen Tsai ◽  
Ansari M. Aleem ◽  
Jennyfer Tena ◽  
Mirella Rivera-Velazquez ◽  
Harman Singh Brah ◽  
...  
Keyword(s):  
Human Platelet ◽  
Inhibitor Development ◽  
12 Lipoxygenase

scholarly journals Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

2011 ◽  
Vol 54 (15) ◽  
pp. 5485-5497 ◽  
Author(s):  
Victor Kenyon ◽  
Ganesha Rai ◽  
Ajit Jadhav ◽  
Lena Schultz ◽  
Michelle Armstrong ◽  
...  
Keyword(s):  
Human Platelet ◽  
Selective Inhibitors ◽  
12 Lipoxygenase

scholarly journals Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase

Biochemistry ◽  
2018 ◽  
Vol 58 (6) ◽  
pp. 848-857 ◽  
Author(s):  
Ansari Mukhtar Aleem ◽  
Wan-Chen Tsai ◽  
Jennyfer Tena ◽  
Gabriella Alvarez ◽  
Joshua Deschamps ◽  
...  
Keyword(s):  
Human Platelet ◽  
Substrate Binding ◽  
12 Lipoxygenase

Human Platelet 12-Lipoxygenase, New Findings about Its Activity, Membrane Binding and Low-resolution Structure

2008 ◽  
Vol 376 (1) ◽  
pp. 193-209 ◽  
Author(s):  
Ansari M. Aleem ◽  
Jerzy Jankun ◽  
John D. Dignam ◽  
Matthias Walther ◽  
Hartmut Kühn ◽  
...  
Keyword(s):  
Human Platelet ◽  
Membrane Binding ◽  
Low Resolution ◽  
New Findings ◽  
12 Lipoxygenase ◽  
Resolution Structure

Aspirin enhances the sensitivity of human platelet 12-lipoxygenase to inhibition by 15-hete, an endogenous regulator

1985 ◽  
Vol 18 (2) ◽  
pp. 255-259 ◽  
Author(s):  
M. Fleteher-Cieutat ◽  
J.Y. Vanderhoek ◽  
R.W. Bryant ◽  
J.M. Bailey
Keyword(s):  
Human Platelet ◽  
Endogenous Regulator ◽  
12 Lipoxygenase

scholarly journals Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

2012 ◽  
Vol 53 (12) ◽  
pp. 2546-2559 ◽  
Author(s):  
Kenneth N. Ikei ◽  
Jennifer Yeung ◽  
Patrick L. Apopa ◽  
Jesús Ceja ◽  
Joanne Vesci ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Human Platelet ◽  
Lipoxygenase Products ◽  
12 Lipoxygenase
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